The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival
Hepatitis B virus infection (HBV) is a leading cause of increased mortality and morbidity in renal transplant subjects. The purpose of this project was to investigate the prevalence of HBV in patients with renal transplant and compare it with the general population in Duhok city, Iraq. Then, the imp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-11-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/7633 |
| _version_ | 1811315436509200384 |
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| author | Nawfal R Hussein Zana SM Zana Nashwan MR Ibrahim Mahde Saleh Assafi Shameran Daniel |
| author_facet | Nawfal R Hussein Zana SM Zana Nashwan MR Ibrahim Mahde Saleh Assafi Shameran Daniel |
| author_sort | Nawfal R Hussein |
| collection | DOAJ |
| description | Hepatitis B virus infection (HBV) is a leading cause of increased mortality and morbidity in renal transplant subjects. The purpose of this project was to investigate the prevalence of HBV in patients with renal transplant and compare it with the general population in Duhok city, Iraq. Then, the impact of HBV infection on graft function was evaluated. A total of 560 renal transplant subjects and 2975 volunteers were recruited in this study. All subjects were examined for HB surface antigen (HBsAg) positivity. Then, all HBsAg positive subjects were tested for viral load, alanine transaminase (ALT), aspartate aminotransferase (AST), serum creatinine and HBV profile. All HBsAg positive renal transplant subjects received treatment and were followed up for 24 months. It was found that 6/560 (1.1%) of the renal transplant subjects were HBsAg positive while 30/2975 (1.09%) of the volunteers were positive for HBsAg (P>0.05). After initiation of medications, viral load became undetected within 6 months of treatment. Serum creatinine levels were normal at the end of the study. No major side effects were recorded. The prevalence of HBV in renal transplant subjects was similar to the prevalence in general population. HBV infection did not show any negative effect on the graft function. Further study is needed with a larger sample size to explore the long term effect of the infection on graft functionality. |
| first_indexed | 2024-04-13T11:30:12Z |
| format | Article |
| id | doaj.art-df48164e38d942b2848afd29e3769ed6 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-13T11:30:12Z |
| publishDate | 2019-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-df48164e38d942b2848afd29e3769ed62022-12-22T02:48:35ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942019-11-0157610.18502/acta.v57i6.18847633The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft SurvivalNawfal R Hussein0Zana SM Zana1Nashwan MR Ibrahim2Mahde Saleh Assafi3Shameran Daniel4Department of Biomedical Sciences, College of Medicine, University of Zakho, Kurdistan Region, Iraq.Department of Internal Medicine, College of Medicine, University of Duhok, Duhok, Iraq.Department of Surgery, College of Medicine, University of Duhok, Duhok, Iraq.Department of Biology, School of Sciences, University of Duhok, Duhok, Iraq.Infection Control Unit, Directorate of Health, Duhok, Iraq.Hepatitis B virus infection (HBV) is a leading cause of increased mortality and morbidity in renal transplant subjects. The purpose of this project was to investigate the prevalence of HBV in patients with renal transplant and compare it with the general population in Duhok city, Iraq. Then, the impact of HBV infection on graft function was evaluated. A total of 560 renal transplant subjects and 2975 volunteers were recruited in this study. All subjects were examined for HB surface antigen (HBsAg) positivity. Then, all HBsAg positive subjects were tested for viral load, alanine transaminase (ALT), aspartate aminotransferase (AST), serum creatinine and HBV profile. All HBsAg positive renal transplant subjects received treatment and were followed up for 24 months. It was found that 6/560 (1.1%) of the renal transplant subjects were HBsAg positive while 30/2975 (1.09%) of the volunteers were positive for HBsAg (P>0.05). After initiation of medications, viral load became undetected within 6 months of treatment. Serum creatinine levels were normal at the end of the study. No major side effects were recorded. The prevalence of HBV in renal transplant subjects was similar to the prevalence in general population. HBV infection did not show any negative effect on the graft function. Further study is needed with a larger sample size to explore the long term effect of the infection on graft functionality.https://acta.tums.ac.ir/index.php/acta/article/view/7633HBVRenal transplantKidney transplantDuhokIraq |
| spellingShingle | Nawfal R Hussein Zana SM Zana Nashwan MR Ibrahim Mahde Saleh Assafi Shameran Daniel The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival Acta Medica Iranica HBV Renal transplant Kidney transplant Duhok Iraq |
| title | The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival |
| title_full | The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival |
| title_fullStr | The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival |
| title_full_unstemmed | The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival |
| title_short | The Prevalence of HBV Infection in Renal Transplant Recipients and the Impact of Infection on Graft Survival |
| title_sort | prevalence of hbv infection in renal transplant recipients and the impact of infection on graft survival |
| topic | HBV Renal transplant Kidney transplant Duhok Iraq |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/7633 |
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