Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy
Aim:To evaluate the variables affecting prognostic factors in patients with salivary gland cancer who have received surgery followed by radiotherapy (RT).Materials and Methods:Fifty-three patients with major and minor salivary gland cancer were treated with curative surgery and postoperative RT betw...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2021-08-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/survival-outcomes-and-prognostic-factors-in-saliva/44762
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| author | Mürsel DÜZOVA Tahir Sedat TURKAN |
| author_facet | Mürsel DÜZOVA Tahir Sedat TURKAN |
| author_sort | Mürsel DÜZOVA |
| collection | DOAJ |
| description | Aim:To evaluate the variables affecting prognostic factors in patients with salivary gland cancer who have received surgery followed by radiotherapy (RT).Materials and Methods:Fifty-three patients with major and minor salivary gland cancer were treated with curative surgery and postoperative RT between 1993 and 2011. We evaluated patients with regard to overall survival, locoregional recurrence-free survival, disease free survival, and distant metastasis-free survival.Results:The median follow-up period was 40 (8-174) months. The rates of local control, distant metastasis-free, disease-free survival and overall survival after 10 years were 65%, 57,7%, 38,8%, and 48,2%, respectively. In univariate analysis, histological subtype, histologic grade, extraglandular extension and delivered dose of RT were found to be as prognostic factors affecting locoregional recurrence-free survival; gender, histological subtype, extraglandular extension influenced disease-free survival; overall survival was only affected by age. In multivariate analysis, locoregional recurrence-free survival was affected by histologic grade and dose of RT (60 Gy< better prognosis); distant metastasis-free survival was affected by histological subtype; disease-free survival was affected by histological subtype, histologic grade, and lymph node status; overall survival was affected by lymph node status, extraglandular extension, and dose of RT (60 Gy< better prognosis).Conclusion:Several prognostic factors affecting local control, distant metastases, and overall survival were found. Postoperative RT is an effective treatment modality that increases local control and overall survival in patients with Salivary Gland Carcinoma at doses over 60 Gy. |
| first_indexed | 2024-04-10T11:59:36Z |
| format | Article |
| id | doaj.art-df488847086e4480b6b78ed27f37edb4 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T11:59:36Z |
| publishDate | 2021-08-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-df488847086e4480b6b78ed27f37edb42023-02-15T16:16:41ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622021-08-019210811510.4274/nkmj.galenos.2021.2193113049054Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant RadiotherapyMürsel DÜZOVA0Tahir Sedat TURKAN1 Selçuk Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Konya, Türkiye Kadıköy Florence Nightingale Hastanesi, Radyasyon Onkolojisi Kliniği, İstanbul, Türkiye Aim:To evaluate the variables affecting prognostic factors in patients with salivary gland cancer who have received surgery followed by radiotherapy (RT).Materials and Methods:Fifty-three patients with major and minor salivary gland cancer were treated with curative surgery and postoperative RT between 1993 and 2011. We evaluated patients with regard to overall survival, locoregional recurrence-free survival, disease free survival, and distant metastasis-free survival.Results:The median follow-up period was 40 (8-174) months. The rates of local control, distant metastasis-free, disease-free survival and overall survival after 10 years were 65%, 57,7%, 38,8%, and 48,2%, respectively. In univariate analysis, histological subtype, histologic grade, extraglandular extension and delivered dose of RT were found to be as prognostic factors affecting locoregional recurrence-free survival; gender, histological subtype, extraglandular extension influenced disease-free survival; overall survival was only affected by age. In multivariate analysis, locoregional recurrence-free survival was affected by histologic grade and dose of RT (60 Gy< better prognosis); distant metastasis-free survival was affected by histological subtype; disease-free survival was affected by histological subtype, histologic grade, and lymph node status; overall survival was affected by lymph node status, extraglandular extension, and dose of RT (60 Gy< better prognosis).Conclusion:Several prognostic factors affecting local control, distant metastases, and overall survival were found. Postoperative RT is an effective treatment modality that increases local control and overall survival in patients with Salivary Gland Carcinoma at doses over 60 Gy. http://namikkemalmedj.com/archives/archive-detail/article-preview/survival-outcomes-and-prognostic-factors-in-saliva/44762 salivary gland cancerradiotherapyprognostic factor |
| spellingShingle | Mürsel DÜZOVA Tahir Sedat TURKAN Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy Namık Kemal Tıp Dergisi salivary gland cancer radiotherapy prognostic factor |
| title | Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy |
| title_full | Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy |
| title_fullStr | Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy |
| title_full_unstemmed | Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy |
| title_short | Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy |
| title_sort | survival outcomes and prognostic factors in salivary gland cancers treated by surgery and adjuvant radiotherapy |
| topic | salivary gland cancer radiotherapy prognostic factor |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/survival-outcomes-and-prognostic-factors-in-saliva/44762
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| work_keys_str_mv | AT murselduzova survivaloutcomesandprognosticfactorsinsalivaryglandcancerstreatedbysurgeryandadjuvantradiotherapy AT tahirsedatturkan survivaloutcomesandprognosticfactorsinsalivaryglandcancerstreatedbysurgeryandadjuvantradiotherapy |