A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is the second most common cancer in liver, with a high recurrence rate after surgery. Recently, we identified a CD11b-CD169-based myeloid response score (MRS), which showed remarkable prognostic potential in hepatocellular carcinoma (HCC). Here, we aimed to ver...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.742953/full |
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| author | Jing Liang Hui Zhou Hui Zhou Xiang-Qi Huang Yan-Fei Liu Lei Zhang Dan He Yongmei Cui Jinrui Guo Kunpeng Hu Chong Wu |
| author_facet | Jing Liang Hui Zhou Hui Zhou Xiang-Qi Huang Yan-Fei Liu Lei Zhang Dan He Yongmei Cui Jinrui Guo Kunpeng Hu Chong Wu |
| author_sort | Jing Liang |
| collection | DOAJ |
| description | Intrahepatic cholangiocarcinoma (iCCA) is the second most common cancer in liver, with a high recurrence rate after surgery. Recently, we identified a CD11b-CD169-based myeloid response score (MRS), which showed remarkable prognostic potential in hepatocellular carcinoma (HCC). Here, we aimed to verify the prognostic value of the MRS in iCCA and establish an MRS-based nomogram to predict the postoperative prognosis of iCCA patients. From April 2005 to March 2017, a total of 84 patients from the Third Affiliated Hospital of Sun Yat-sen University were enrolled. Preoperative clinical information and surgical specimens of enrolled patients were collected. Among these, tissues from 75 patients passed the clinical data quality control and the staining quality control. The protein expression of CD11b and CD169 in iCCA samples were detected by immunohistochemistry (IHC). Kaplan-Meier analysis and receiver operating characteristic (ROC) curves revealed that the MRS had a high discriminatory ability for predicting the time to recurrence (TTR) of iCCA patients after surgery. Three independent risk factors selected by a Cox proportional hazards regression analysis, namely, the MRS, the tumor size and the status of vascular invasion, were included to construct a nomogram to predict the recurrence of iCCA after resection surgery. ROC curves, calibration analysis and decision curve analysis (DCA) suggested that this nomogram had notable discriminatory power, stability and clinical usefulness in predicting the postoperative recurrence. Together, we explored the prognostic value of the MRS in iCCA, and constructed an MRS-based nomogram which may help to predict postoperative recurrence and aid clinical decisions for iCCA patients. |
| first_indexed | 2024-12-22T03:50:11Z |
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| language | English |
| last_indexed | 2024-12-22T03:50:11Z |
| publishDate | 2021-10-01 |
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| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-df4a0154aac94bef9d6f27a970804d332022-12-21T18:40:01ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-10-01810.3389/fmolb.2021.742953742953A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic CholangiocarcinomaJing Liang0Hui Zhou1Hui Zhou2Xiang-Qi Huang3Yan-Fei Liu4Lei Zhang5Dan He6Yongmei Cui7Jinrui Guo8Kunpeng Hu9Chong Wu10Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Gastrointestinal Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Biliary-Pancreatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, ChinaIntrahepatic cholangiocarcinoma (iCCA) is the second most common cancer in liver, with a high recurrence rate after surgery. Recently, we identified a CD11b-CD169-based myeloid response score (MRS), which showed remarkable prognostic potential in hepatocellular carcinoma (HCC). Here, we aimed to verify the prognostic value of the MRS in iCCA and establish an MRS-based nomogram to predict the postoperative prognosis of iCCA patients. From April 2005 to March 2017, a total of 84 patients from the Third Affiliated Hospital of Sun Yat-sen University were enrolled. Preoperative clinical information and surgical specimens of enrolled patients were collected. Among these, tissues from 75 patients passed the clinical data quality control and the staining quality control. The protein expression of CD11b and CD169 in iCCA samples were detected by immunohistochemistry (IHC). Kaplan-Meier analysis and receiver operating characteristic (ROC) curves revealed that the MRS had a high discriminatory ability for predicting the time to recurrence (TTR) of iCCA patients after surgery. Three independent risk factors selected by a Cox proportional hazards regression analysis, namely, the MRS, the tumor size and the status of vascular invasion, were included to construct a nomogram to predict the recurrence of iCCA after resection surgery. ROC curves, calibration analysis and decision curve analysis (DCA) suggested that this nomogram had notable discriminatory power, stability and clinical usefulness in predicting the postoperative recurrence. Together, we explored the prognostic value of the MRS in iCCA, and constructed an MRS-based nomogram which may help to predict postoperative recurrence and aid clinical decisions for iCCA patients.https://www.frontiersin.org/articles/10.3389/fmolb.2021.742953/fullCD11bCD169nomogramintrahepatic cholangiocarcinomarecurrence |
| spellingShingle | Jing Liang Hui Zhou Hui Zhou Xiang-Qi Huang Yan-Fei Liu Lei Zhang Dan He Yongmei Cui Jinrui Guo Kunpeng Hu Chong Wu A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma Frontiers in Molecular Biosciences CD11b CD169 nomogram intrahepatic cholangiocarcinoma recurrence |
| title | A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma |
| title_full | A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma |
| title_fullStr | A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma |
| title_full_unstemmed | A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma |
| title_short | A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma |
| title_sort | myeloid signature based nomogram predicts the postoperative recurrence of intrahepatic cholangiocarcinoma |
| topic | CD11b CD169 nomogram intrahepatic cholangiocarcinoma recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.742953/full |
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