CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems

CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems

CRISPR-Cas adaptive immunity systems of bacteria and archaea insert fragments of virus or plasmid DNA as spacer sequences into CRISPR repeat loci. Processed transcripts encompassing these spacers guide the cleavage of the cognate foreign DNA or RNA. Most CRISPR-Cas loci, in addition to recognized ca...

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Bibliographic Details
Main Authors: Kira eMakarova, Vivek eAnantharaman, Nick eGrishin, Eugene V. Koonin, L eAravind
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Genetics
Subjects:
DNA-Binding Proteins
Endonucleases
Nucleotides
toxins
Nuclease
Plasmid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00102/full

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