Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials
<p>Abstract</p> <p>Background</p> <p>Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. I...
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| Format: | Article |
| Language: | English |
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BMC
2001-11-01
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| Series: | BMC Musculoskeletal Disorders |
| Online Access: | http://www.biomedcentral.com/1471-2474/2/7 |
| _version_ | 1819121709582647296 |
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| author | Bell-Syer Sally EM Torgerson David J |
| author_facet | Bell-Syer Sally EM Torgerson David J |
| author_sort | Bell-Syer Sally EM |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures.</p> <p>Methods</p> <p>We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT.</p> <p>Results</p> <p>We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%).</p> <p>Conclusions</p> <p>This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.</p> |
| first_indexed | 2024-12-22T06:40:52Z |
| format | Article |
| id | doaj.art-df4aed92a676409c95a893b5ce711772 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-22T06:40:52Z |
| publishDate | 2001-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-df4aed92a676409c95a893b5ce7117722022-12-21T18:35:27ZengBMCBMC Musculoskeletal Disorders1471-24742001-11-0121710.1186/1471-2474-2-7Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trialsBell-Syer Sally EMTorgerson David J<p>Abstract</p> <p>Background</p> <p>Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures.</p> <p>Methods</p> <p>We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT.</p> <p>Results</p> <p>We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%).</p> <p>Conclusions</p> <p>This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.</p>http://www.biomedcentral.com/1471-2474/2/7 |
| spellingShingle | Bell-Syer Sally EM Torgerson David J Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials BMC Musculoskeletal Disorders |
| title | Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials |
| title_full | Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials |
| title_fullStr | Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials |
| title_full_unstemmed | Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials |
| title_short | Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials |
| title_sort | hormone replacement therapy and prevention of vertebral fractures a meta analysis of randomised trials |
| url | http://www.biomedcentral.com/1471-2474/2/7 |
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