The biological applications of DNA nanomaterials: current challenges and future directions
Abstract DNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades, including tissue regeneration, disease prevention, inflammation inhibition, bioimaging, biosensing, diagnosis, antitumor dru...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-10-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-021-00727-9 |
| _version_ | 1819026920751235072 |
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| author | Wenjuan Ma Yuxi Zhan Yuxin Zhang Chenchen Mao Xueping Xie Yunfeng Lin |
| author_facet | Wenjuan Ma Yuxi Zhan Yuxin Zhang Chenchen Mao Xueping Xie Yunfeng Lin |
| author_sort | Wenjuan Ma |
| collection | DOAJ |
| description | Abstract DNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades, including tissue regeneration, disease prevention, inflammation inhibition, bioimaging, biosensing, diagnosis, antitumor drug delivery, and therapeutics. With the rapid progress in DNA nanotechnology, multitudinous DNA nanomaterials have been designed with different shape and size based on the classic Watson–Crick base-pairing for molecular self-assembly. Some DNA materials could functionally change cell biological behaviors, such as cell migration, cell proliferation, cell differentiation, autophagy, and anti-inflammatory effects. Some single-stranded DNAs (ssDNAs) or RNAs with secondary structures via self-pairing, named aptamer, possess the ability of targeting, which are selected by systematic evolution of ligands by exponential enrichment (SELEX) and applied for tumor targeted diagnosis and treatment. Some DNA nanomaterials with three-dimensional (3D) nanostructures and stable structures are investigated as drug carrier systems to delivery multiple antitumor medicine or gene therapeutic agents. While the functional DNA nanostructures have promoted the development of the DNA nanotechnology with innovative designs and preparation strategies, and also proved with great potential in the biological and medical use, there is still a long way to go for the eventual application of DNA materials in real life. Here in this review, we conducted a comprehensive survey of the structural development history of various DNA nanomaterials, introduced the principles of different DNA nanomaterials, summarized their biological applications in different fields, and discussed the current challenges and further directions that could help to achieve their applications in the future. |
| first_indexed | 2024-12-21T05:34:15Z |
| format | Article |
| id | doaj.art-df4c50ba479544deb6862e3448e78688 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-12-21T05:34:15Z |
| publishDate | 2021-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-df4c50ba479544deb6862e3448e786882022-12-21T19:14:27ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-10-016112810.1038/s41392-021-00727-9The biological applications of DNA nanomaterials: current challenges and future directionsWenjuan Ma0Yuxi Zhan1Yuxin Zhang2Chenchen Mao3Xueping Xie4Yunfeng Lin5State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract DNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades, including tissue regeneration, disease prevention, inflammation inhibition, bioimaging, biosensing, diagnosis, antitumor drug delivery, and therapeutics. With the rapid progress in DNA nanotechnology, multitudinous DNA nanomaterials have been designed with different shape and size based on the classic Watson–Crick base-pairing for molecular self-assembly. Some DNA materials could functionally change cell biological behaviors, such as cell migration, cell proliferation, cell differentiation, autophagy, and anti-inflammatory effects. Some single-stranded DNAs (ssDNAs) or RNAs with secondary structures via self-pairing, named aptamer, possess the ability of targeting, which are selected by systematic evolution of ligands by exponential enrichment (SELEX) and applied for tumor targeted diagnosis and treatment. Some DNA nanomaterials with three-dimensional (3D) nanostructures and stable structures are investigated as drug carrier systems to delivery multiple antitumor medicine or gene therapeutic agents. While the functional DNA nanostructures have promoted the development of the DNA nanotechnology with innovative designs and preparation strategies, and also proved with great potential in the biological and medical use, there is still a long way to go for the eventual application of DNA materials in real life. Here in this review, we conducted a comprehensive survey of the structural development history of various DNA nanomaterials, introduced the principles of different DNA nanomaterials, summarized their biological applications in different fields, and discussed the current challenges and further directions that could help to achieve their applications in the future.https://doi.org/10.1038/s41392-021-00727-9 |
| spellingShingle | Wenjuan Ma Yuxi Zhan Yuxin Zhang Chenchen Mao Xueping Xie Yunfeng Lin The biological applications of DNA nanomaterials: current challenges and future directions Signal Transduction and Targeted Therapy |
| title | The biological applications of DNA nanomaterials: current challenges and future directions |
| title_full | The biological applications of DNA nanomaterials: current challenges and future directions |
| title_fullStr | The biological applications of DNA nanomaterials: current challenges and future directions |
| title_full_unstemmed | The biological applications of DNA nanomaterials: current challenges and future directions |
| title_short | The biological applications of DNA nanomaterials: current challenges and future directions |
| title_sort | biological applications of dna nanomaterials current challenges and future directions |
| url | https://doi.org/10.1038/s41392-021-00727-9 |
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