Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging
In mild cognitive impairment (MCI), cognitive decline is associated with abnormal changes of cerebral blood flow (CBF). Arterial spin labeling magnetic resonance imaging (ASL-MRI) is an effective method for assessing regional cerebral blood flow (rCBF). However, the CBF estimated via ASL-MRI in MCI...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.961344/full |
| _version_ | 1811337607952465920 |
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| author | Tong Tang Tong Tang Tong Tang Li Huang Li Huang Li Huang Yusi Zhang Yusi Zhang Yusi Zhang Zuanfang Li Zuanfang Li Shengxiang Liang Shengxiang Liang Shengxiang Liang |
| author_facet | Tong Tang Tong Tang Tong Tang Li Huang Li Huang Li Huang Yusi Zhang Yusi Zhang Yusi Zhang Zuanfang Li Zuanfang Li Shengxiang Liang Shengxiang Liang Shengxiang Liang |
| author_sort | Tong Tang |
| collection | DOAJ |
| description | In mild cognitive impairment (MCI), cognitive decline is associated with abnormal changes of cerebral blood flow (CBF). Arterial spin labeling magnetic resonance imaging (ASL-MRI) is an effective method for assessing regional cerebral blood flow (rCBF). However, the CBF estimated via ASL-MRI in MCI often differs between studies, and the consistency of CBF changes in MCI is unclear. In this study, 13 ASL-MRI studies with 495 MCI patients and 441 health controls were screened out from PubMed, Embase, Cochrane, Web of Science, Wanfang, and CNKI. An activation likelihood estimation (ALE) meta-analysis was performed to explore the brain regions with abnormal CBF in MCI. It showed that the decreased CBF in MCI was identified in the precuneus, inferior parietal lobule (IPL), superior occipital gyrus (SOG), middle temporal gyrus (MTG), and middle occipital gyrus (MOG), while the increased CBF in MCI was identified in the lentiform nucleus (LN) compared with healthy controls. The study characterized the abnormal pattern of regional CBF in MCI, which would promote our knowledge of MCI and might be used as a biomarker in clinic.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=259633. |
| first_indexed | 2024-04-13T17:57:28Z |
| format | Article |
| id | doaj.art-df4ce6f95d944fb4be5cb093b77890b0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T17:57:28Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-df4ce6f95d944fb4be5cb093b77890b02022-12-22T02:36:25ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.961344961344Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imagingTong Tang0Tong Tang1Tong Tang2Li Huang3Li Huang4Li Huang5Yusi Zhang6Yusi Zhang7Yusi Zhang8Zuanfang Li9Zuanfang Li10Shengxiang Liang11Shengxiang Liang12Shengxiang Liang13National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaRehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaRehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaRehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaInnovation and Transformation Center, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaRehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaTraditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaIn mild cognitive impairment (MCI), cognitive decline is associated with abnormal changes of cerebral blood flow (CBF). Arterial spin labeling magnetic resonance imaging (ASL-MRI) is an effective method for assessing regional cerebral blood flow (rCBF). However, the CBF estimated via ASL-MRI in MCI often differs between studies, and the consistency of CBF changes in MCI is unclear. In this study, 13 ASL-MRI studies with 495 MCI patients and 441 health controls were screened out from PubMed, Embase, Cochrane, Web of Science, Wanfang, and CNKI. An activation likelihood estimation (ALE) meta-analysis was performed to explore the brain regions with abnormal CBF in MCI. It showed that the decreased CBF in MCI was identified in the precuneus, inferior parietal lobule (IPL), superior occipital gyrus (SOG), middle temporal gyrus (MTG), and middle occipital gyrus (MOG), while the increased CBF in MCI was identified in the lentiform nucleus (LN) compared with healthy controls. The study characterized the abnormal pattern of regional CBF in MCI, which would promote our knowledge of MCI and might be used as a biomarker in clinic.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=259633.https://www.frontiersin.org/articles/10.3389/fnagi.2022.961344/fullmild cognitive impairmentcerebral blood flowarterial spin labelingmeta-analysisactivation likelihood estimation |
| spellingShingle | Tong Tang Tong Tang Tong Tang Li Huang Li Huang Li Huang Yusi Zhang Yusi Zhang Yusi Zhang Zuanfang Li Zuanfang Li Shengxiang Liang Shengxiang Liang Shengxiang Liang Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging Frontiers in Aging Neuroscience mild cognitive impairment cerebral blood flow arterial spin labeling meta-analysis activation likelihood estimation |
| title | Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging |
| title_full | Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging |
| title_fullStr | Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging |
| title_full_unstemmed | Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging |
| title_short | Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging |
| title_sort | aberrant pattern of regional cerebral blood flow in mild cognitive impairment a meta analysis of arterial spin labeling magnetic resonance imaging |
| topic | mild cognitive impairment cerebral blood flow arterial spin labeling meta-analysis activation likelihood estimation |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.961344/full |
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