The Rotavirus Vaccine Landscape, an Update
Rotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/5/520 |
| _version_ | 1797536279122935808 |
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| author | Roberto Cárcamo-Calvo Carlos Muñoz Javier Buesa Jesús Rodríguez-Díaz Roberto Gozalbo-Rovira |
| author_facet | Roberto Cárcamo-Calvo Carlos Muñoz Javier Buesa Jesús Rodríguez-Díaz Roberto Gozalbo-Rovira |
| author_sort | Roberto Cárcamo-Calvo |
| collection | DOAJ |
| description | Rotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are still preventable. The two main vaccines currently deployed, Rotarix and RotaTeq, both live oral vaccines, have been shown to be less effective in developing countries. In addition, they have been associated with a slight risk of intussusception, and the need for cold chain maintenance limits the accessibility of these vaccines to certain areas, leaving 65% of children worldwide unvaccinated and therefore unprotected. Against this backdrop, here we review the main vaccines under development and the state of the art on potential alternatives. |
| first_indexed | 2024-03-10T11:57:25Z |
| format | Article |
| id | doaj.art-df4e8483189d4b4988644bef9ccd02af |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T11:57:25Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-df4e8483189d4b4988644bef9ccd02af2023-11-21T17:12:11ZengMDPI AGPathogens2076-08172021-04-0110552010.3390/pathogens10050520The Rotavirus Vaccine Landscape, an UpdateRoberto Cárcamo-Calvo0Carlos Muñoz1Javier Buesa2Jesús Rodríguez-Díaz3Roberto Gozalbo-Rovira4Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, SpainDepartment of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, SpainDepartment of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, SpainDepartment of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, SpainDepartment of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, SpainRotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are still preventable. The two main vaccines currently deployed, Rotarix and RotaTeq, both live oral vaccines, have been shown to be less effective in developing countries. In addition, they have been associated with a slight risk of intussusception, and the need for cold chain maintenance limits the accessibility of these vaccines to certain areas, leaving 65% of children worldwide unvaccinated and therefore unprotected. Against this backdrop, here we review the main vaccines under development and the state of the art on potential alternatives.https://www.mdpi.com/2076-0817/10/5/520rotavirusgastroenteritisvaccineintussusceptiondiarrhea |
| spellingShingle | Roberto Cárcamo-Calvo Carlos Muñoz Javier Buesa Jesús Rodríguez-Díaz Roberto Gozalbo-Rovira The Rotavirus Vaccine Landscape, an Update Pathogens rotavirus gastroenteritis vaccine intussusception diarrhea |
| title | The Rotavirus Vaccine Landscape, an Update |
| title_full | The Rotavirus Vaccine Landscape, an Update |
| title_fullStr | The Rotavirus Vaccine Landscape, an Update |
| title_full_unstemmed | The Rotavirus Vaccine Landscape, an Update |
| title_short | The Rotavirus Vaccine Landscape, an Update |
| title_sort | rotavirus vaccine landscape an update |
| topic | rotavirus gastroenteritis vaccine intussusception diarrhea |
| url | https://www.mdpi.com/2076-0817/10/5/520 |
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