Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma

Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is the leading cause of primary liver cancers. Surveillance of individuals at specific risk of developing HCC, early diagnostic markers, and new therapeutic approaches are essential to obtain a reduction in disease-related mortality. Apurinic/apyrim...

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Bibliographic Details
Main Authors: Veronica Bazzani, Arianna Barchiesi, Dorota Radecka, Riccardo Pravisani, Antonio Guadagno, Carla Di Loreto, Umberto Baccarani, Carlo Vascotto
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
APE1
MIA pathway
Mitochondria
mtDNA damage
Base excision repair pathway
Online Access:http://link.springer.com/article/10.1186/s12885-020-07258-6

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