Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2008-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024 |
| _version_ | 1818848450628812800 |
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| author | Fabíola Branco Filippin Liliete Canes Souza Raul Cavalcante Maranhão |
| author_facet | Fabíola Branco Filippin Liliete Canes Souza Raul Cavalcante Maranhão |
| author_sort | Fabíola Branco Filippin |
| collection | DOAJ |
| description | Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells. |
| first_indexed | 2024-12-19T06:17:32Z |
| format | Article |
| id | doaj.art-df537bb63ddd44f19c8d4397f6ac9fa4 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-19T06:17:32Z |
| publishDate | 2008-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-df537bb63ddd44f19c8d4397f6ac9fa42022-12-21T20:32:49ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642008-01-0131359159410.1590/S0100-40422008000300024Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activityFabíola Branco FilippinLiliete Canes SouzaRaul Cavalcante MaranhãoAmphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024amphotericin Blipid nanoemulsiondelivery system |
| spellingShingle | Fabíola Branco Filippin Liliete Canes Souza Raul Cavalcante Maranhão Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity Química Nova amphotericin B lipid nanoemulsion delivery system |
| title | Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity |
| title_full | Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity |
| title_fullStr | Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity |
| title_full_unstemmed | Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity |
| title_short | Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity |
| title_sort | amphotericin b associated with triglyceride rich nanoemulsion stability studies and in vitro antifungal activity |
| topic | amphotericin B lipid nanoemulsion delivery system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024 |
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