The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning
Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolonga...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-09-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=204 |
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| author | Müjgan Büyükdeligöz Nil Hocaoğlu Kubilay Oransay Yeşim Tunçok Şule Kalkan |
| author_facet | Müjgan Büyükdeligöz Nil Hocaoğlu Kubilay Oransay Yeşim Tunçok Şule Kalkan |
| author_sort | Müjgan Büyükdeligöz |
| collection | DOAJ |
| description | Background: Citalopram is a selective serotonin reuptake
inhibitor that requires routine cardiac monitoring
to prevent a toxic dose. Prolongation of the QT
interval has been observed in acute citalopram poisoning.
Our previous experimental study showed that citalopram
may be lead to QT prolongation by stimulating
adenosine A1 receptors without affecting the release of
adenosine.
Aims: We examined the effects of adenosine receptor
antagonists in reversing the cardiovascular toxic effects
induced by citalopram in rats.
Study Design: Animal experimentation.
Methods: Rats were divided into three groups randomly
(n=7 for each group). Sodium cromoglycate (20
mg/kg) was administered to all rats to inhibit adenosine
A3 receptor mast cell activation. Citalopram toxicity
was achieved by citalopram infusion (4 mg/kg/min) for
20 minutes. After citalopram infusion, in the control
group (Group 1), rats were given an infusion of dextrose
solution for 60 minutes. In treatment groups, the
selective adenosine A1 antagonist DPCPX (Group 2,
8-cyclopentyl-1,3-dipropylxanthine, 20 μg/kg/min) or
the selective A2a antagonist CSC (Group 3, 8-(3-chlorostyryl)caffeine,
24 μg/kg/min) was infused for 60
minutes. Mean arterial pressure (MAP), heart rate
(HR), QRS duration and QT interval measurements
were followed during the experiment period. Statistical
analysis was performed by ANOVA followed by
Tukey’s multiple comparison tests.
Results: Citalopram infusion reduced MAP and HR
and prolonged the QT interval. It did not cause any
significant difference in QRS duration in any group.
When compared to the control group, DPCPX after
citalopram infusion shortened the prolongation of the
QT interval after 40, 50 and 60 minutes (p<0.01). DPCPX
infusion shortened the prolongation of the QT
interval at 60 minutes compared with the CSC group
(p<0.05). CSC infusion shortened the prolongation of
the QT at 60 minutes compared with the control group
(p<0.05).
Conclusion: DPCPX improved QT interval prolongation
in citalopram toxicity. The results of this study
show that mechanism of cardiovascular toxicity induced
by citalopram may be related adenosine A1 receptor
stimulation. Adenosine A1 receptor antagonists
may be used for the treatment of citalopram toxicity. |
| first_indexed | 2024-04-10T12:20:36Z |
| format | Article |
| id | doaj.art-df5479977c6b4c0e92eb2d858895487e |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:20:36Z |
| publishDate | 2015-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-df5479977c6b4c0e92eb2d858895487e2023-02-15T16:15:29ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312015-09-0132330330810.5152/balkanmedj.2015.15932The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of PoisoningMüjgan Büyükdeligöz0Nil Hocaoğlu1Kubilay Oransay2Yeşim Tunçok3Şule Kalkan4Department of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, İzmir, TurkeyDepartment of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, İzmir, TurkeyDepartment of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, İzmir, TurkeyDepartment of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, İzmir, TurkeyDepartment of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, İzmir, TurkeyBackground: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenosine A1 receptors without affecting the release of adenosine. Aims: We examined the effects of adenosine receptor antagonists in reversing the cardiovascular toxic effects induced by citalopram in rats. Study Design: Animal experimentation. Methods: Rats were divided into three groups randomly (n=7 for each group). Sodium cromoglycate (20 mg/kg) was administered to all rats to inhibit adenosine A3 receptor mast cell activation. Citalopram toxicity was achieved by citalopram infusion (4 mg/kg/min) for 20 minutes. After citalopram infusion, in the control group (Group 1), rats were given an infusion of dextrose solution for 60 minutes. In treatment groups, the selective adenosine A1 antagonist DPCPX (Group 2, 8-cyclopentyl-1,3-dipropylxanthine, 20 μg/kg/min) or the selective A2a antagonist CSC (Group 3, 8-(3-chlorostyryl)caffeine, 24 μg/kg/min) was infused for 60 minutes. Mean arterial pressure (MAP), heart rate (HR), QRS duration and QT interval measurements were followed during the experiment period. Statistical analysis was performed by ANOVA followed by Tukey’s multiple comparison tests. Results: Citalopram infusion reduced MAP and HR and prolonged the QT interval. It did not cause any significant difference in QRS duration in any group. When compared to the control group, DPCPX after citalopram infusion shortened the prolongation of the QT interval after 40, 50 and 60 minutes (p<0.01). DPCPX infusion shortened the prolongation of the QT interval at 60 minutes compared with the CSC group (p<0.05). CSC infusion shortened the prolongation of the QT at 60 minutes compared with the control group (p<0.05). Conclusion: DPCPX improved QT interval prolongation in citalopram toxicity. The results of this study show that mechanism of cardiovascular toxicity induced by citalopram may be related adenosine A1 receptor stimulation. Adenosine A1 receptor antagonists may be used for the treatment of citalopram toxicity.http://balkanmedicaljournal.org/text.php?lang=en&id=204Adenosine receptor antagonistscitalopramcardiovascular toxicityQT prolongationrat |
| spellingShingle | Müjgan Büyükdeligöz Nil Hocaoğlu Kubilay Oransay Yeşim Tunçok Şule Kalkan The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning Balkan Medical Journal Adenosine receptor antagonists citalopram cardiovascular toxicity QT prolongation rat |
| title | The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning |
| title_full | The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning |
| title_fullStr | The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning |
| title_full_unstemmed | The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning |
| title_short | The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning |
| title_sort | effects of the adenosine receptor antagonists on the reverse of cardiovascular toxic effects induced by citalopram in vivo rat model of poisoning |
| topic | Adenosine receptor antagonists citalopram cardiovascular toxicity QT prolongation rat |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=204 |
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