The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease
The ribosome is a macromolecular complex composed of RNA and proteins that interact through an integrated and interconnected network to preserve its ancient core activities. In this review, we emphasize the pivotal role played by RNA-binding proteins as a driving force in the evolution of the curren...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/11/2969 |
| _version_ | 1797460079626158080 |
|---|---|
| author | Caterina Catalanotto Christian Barbato Carlo Cogoni Dario Benelli |
| author_facet | Caterina Catalanotto Christian Barbato Carlo Cogoni Dario Benelli |
| author_sort | Caterina Catalanotto |
| collection | DOAJ |
| description | The ribosome is a macromolecular complex composed of RNA and proteins that interact through an integrated and interconnected network to preserve its ancient core activities. In this review, we emphasize the pivotal role played by RNA-binding proteins as a driving force in the evolution of the current form of the ribosome, underscoring their importance in ensuring accurate protein synthesis. This category of proteins includes both ribosomal proteins and ribosome biogenesis factors. Impairment of their RNA-binding activity can also lead to ribosomopathies, which is a group of disorders characterized by defects in ribosome biogenesis that are detrimental to protein synthesis and cellular homeostasis. A comprehensive understanding of these intricate processes is essential for elucidating the mechanisms underlying the resulting diseases and advancing potential therapeutic interventions. |
| first_indexed | 2024-03-09T17:00:06Z |
| format | Article |
| id | doaj.art-df548ecb0dfa413ba6c2d37b417e04ad |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:00:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-df548ecb0dfa413ba6c2d37b417e04ad2023-11-24T14:30:59ZengMDPI AGBiomedicines2227-90592023-11-011111296910.3390/biomedicines11112969The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and DiseaseCaterina Catalanotto0Christian Barbato1Carlo Cogoni2Dario Benelli3Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, ItalyNational Research Council (CNR), Department of Sense Organs DOS, Institute of Biochemistry and Cell Biology (IBBC), Sapienza University of Rome, 00185 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Rome, ItalyThe ribosome is a macromolecular complex composed of RNA and proteins that interact through an integrated and interconnected network to preserve its ancient core activities. In this review, we emphasize the pivotal role played by RNA-binding proteins as a driving force in the evolution of the current form of the ribosome, underscoring their importance in ensuring accurate protein synthesis. This category of proteins includes both ribosomal proteins and ribosome biogenesis factors. Impairment of their RNA-binding activity can also lead to ribosomopathies, which is a group of disorders characterized by defects in ribosome biogenesis that are detrimental to protein synthesis and cellular homeostasis. A comprehensive understanding of these intricate processes is essential for elucidating the mechanisms underlying the resulting diseases and advancing potential therapeutic interventions.https://www.mdpi.com/2227-9059/11/11/2969ribosomal origins and evolutionRNA-binding proteinsribosomal RNAribosomopathiesDBASBDS |
| spellingShingle | Caterina Catalanotto Christian Barbato Carlo Cogoni Dario Benelli The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease Biomedicines ribosomal origins and evolution RNA-binding proteins ribosomal RNA ribosomopathies DBA SBDS |
| title | The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease |
| title_full | The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease |
| title_fullStr | The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease |
| title_full_unstemmed | The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease |
| title_short | The RNA-Binding Function of Ribosomal Proteins and Ribosome Biogenesis Factors in Human Health and Disease |
| title_sort | rna binding function of ribosomal proteins and ribosome biogenesis factors in human health and disease |
| topic | ribosomal origins and evolution RNA-binding proteins ribosomal RNA ribosomopathies DBA SBDS |
| url | https://www.mdpi.com/2227-9059/11/11/2969 |
| work_keys_str_mv | AT caterinacatalanotto thernabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT christianbarbato thernabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT carlocogoni thernabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT dariobenelli thernabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT caterinacatalanotto rnabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT christianbarbato rnabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT carlocogoni rnabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease AT dariobenelli rnabindingfunctionofribosomalproteinsandribosomebiogenesisfactorsinhumanhealthanddisease |