Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements
Phosphaturic mesenchymal tumors (PMT) are rare neoplasms, which can give rise to a multifaceted syndrome, otherwise called tumor-induced osteomalacia (TIO). Localizing these tumors is crucial to obtain a cure for the phosphate metabolism derangement, which is often the main cause leading the patient...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/8/541 |
| _version_ | 1797585075753189376 |
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| author | Andrea Montanari Maria Giulia Pirini Ludovica Lotrecchiano Lorenzo Di Prinzio Guido Zavatta |
| author_facet | Andrea Montanari Maria Giulia Pirini Ludovica Lotrecchiano Lorenzo Di Prinzio Guido Zavatta |
| author_sort | Andrea Montanari |
| collection | DOAJ |
| description | Phosphaturic mesenchymal tumors (PMT) are rare neoplasms, which can give rise to a multifaceted syndrome, otherwise called tumor-induced osteomalacia (TIO). Localizing these tumors is crucial to obtain a cure for the phosphate metabolism derangement, which is often the main cause leading the patient to seek medical help, because of invalidating physical and neuromuscular symptoms. A proportion of these tumors is completely silent and may grow unnoticed, unless they become large enough to produce pain or discomfort. FGF-23 can be produced by several benign or malignant PMTs. The phosphate metabolism, radiology and histology of these rare tumors must be collectively assessed by a multidisciplinary team aimed at curing the disease locally and improving patients’ quality of life. This narrative review, authored by multiple specialists of a tertiary care hospital center, will describe endocrine, radiological and histological features of these tumors, as well as present surgical and interventional strategies to manage PMTs. |
| first_indexed | 2024-03-11T00:01:44Z |
| format | Article |
| id | doaj.art-df55654a4da74cc097e15ac0d5a5ce7c |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T00:01:44Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-df55654a4da74cc097e15ac0d5a5ce7c2023-11-19T00:46:35ZengMDPI AGCurrent Oncology1198-00521718-77292023-08-013087478748810.3390/curroncol30080541Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism DerangementsAndrea Montanari0Maria Giulia Pirini1Ludovica Lotrecchiano2Lorenzo Di Prinzio3Guido Zavatta4Orthopaedics and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopaedics and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPhosphaturic mesenchymal tumors (PMT) are rare neoplasms, which can give rise to a multifaceted syndrome, otherwise called tumor-induced osteomalacia (TIO). Localizing these tumors is crucial to obtain a cure for the phosphate metabolism derangement, which is often the main cause leading the patient to seek medical help, because of invalidating physical and neuromuscular symptoms. A proportion of these tumors is completely silent and may grow unnoticed, unless they become large enough to produce pain or discomfort. FGF-23 can be produced by several benign or malignant PMTs. The phosphate metabolism, radiology and histology of these rare tumors must be collectively assessed by a multidisciplinary team aimed at curing the disease locally and improving patients’ quality of life. This narrative review, authored by multiple specialists of a tertiary care hospital center, will describe endocrine, radiological and histological features of these tumors, as well as present surgical and interventional strategies to manage PMTs.https://www.mdpi.com/1718-7729/30/8/541phosphaturic tumortumor-induced osteomalaciaFGF-23phosphatoninsurgeryorthopedics |
| spellingShingle | Andrea Montanari Maria Giulia Pirini Ludovica Lotrecchiano Lorenzo Di Prinzio Guido Zavatta Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements Current Oncology phosphaturic tumor tumor-induced osteomalacia FGF-23 phosphatonin surgery orthopedics |
| title | Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements |
| title_full | Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements |
| title_fullStr | Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements |
| title_full_unstemmed | Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements |
| title_short | Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements |
| title_sort | phosphaturic mesenchymal tumors with or without phosphate metabolism derangements |
| topic | phosphaturic tumor tumor-induced osteomalacia FGF-23 phosphatonin surgery orthopedics |
| url | https://www.mdpi.com/1718-7729/30/8/541 |
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