The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

Abstract Background Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases...

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Bibliographic Details
Main Authors: Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller, Fred Schaper
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Subjects:
Interleukin-6
IL-6
Janus kinase
Jak
Gab1
SHP2
Online Access:http://link.springer.com/article/10.1186/s12964-019-0451-2

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