The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1β

The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1β

The common human pathogen Group A Streptococcus (GAS) causes superficial as well as invasive, life-threatening diseases. An increase in the occurrence of invasive GAS infection by strains of the M1 and M89 serotypes has been correlated with increased expression of the genetically and functionally li...

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Bibliographic Details
Main Authors: Elsa Westerlund, Christine Valfridsson, Daisy X. Yi, Jenny J. Persson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
Group A Streptococcus
NADase
P2X7
IL-1β
membrane permeabilization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01385/full

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