Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer
Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes (<i>VEG...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/5/1163 |
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| author | Foteinos-Ioannis Dimitrakopoulos Georgia-Angeliki Koliou Vassiliki Kotoula Kyriaki Papadopoulou Konstantinos Markou Konstantinos Vlachtsis Nikolaos Angouridakis Ilias Karasmanis Angelos Nikolaou Amanda Psyrri Anastasios Visvikis Paris Kosmidis George Fountzilas Angelos Koutras |
| author_facet | Foteinos-Ioannis Dimitrakopoulos Georgia-Angeliki Koliou Vassiliki Kotoula Kyriaki Papadopoulou Konstantinos Markou Konstantinos Vlachtsis Nikolaos Angouridakis Ilias Karasmanis Angelos Nikolaou Amanda Psyrri Anastasios Visvikis Paris Kosmidis George Fountzilas Angelos Koutras |
| author_sort | Foteinos-Ioannis Dimitrakopoulos |
| collection | DOAJ |
| description | Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes (<i>VEGFA</i>, <i>FAS</i>, <i>EDNRA</i> and <i>NBS1</i>) were evaluated regarding their clinical significance in HNC patients. In total, 333 HNC patients were enrolled in this study and 34 variants located on the aforementioned genes were genotyped via Sanger sequencing. LC patients, homozygous A for <i>VEGFA</i> rs13207351, had shorter overall survival (OS) as opposed to homozygous G (Hazard ratio (HR) = 2.06, Wald’s <i>p =</i> 0.017) upon adjustment for age, disease stage, and surgery. Following the dominant model, LC patients carrying the A allele had a marginally significantly higher risk for death (HR = 1.72, <i>p</i> = 0.059). NPC patients heterozygous (CT) for <i>FAS</i> rs2234768 had a marginal but significantly higher risk of death compared to those with homozygosity for the T allele (HR = 2.22, <i>p</i> = 0.056). In conclusion, rs13207351 (<i>VEGFA</i>) and rs2234768 (<i>FAS</i>) polymorphisms seem to have prognostic significance in HNC, with <i>VEGFA</i> rs13207351 showing the most promise in this subgroup of LC patients. |
| first_indexed | 2024-03-10T13:26:35Z |
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| id | doaj.art-df569dd7b0ee407480070cdb12a7bd76 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:26:35Z |
| publishDate | 2021-03-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-df569dd7b0ee407480070cdb12a7bd762023-11-21T09:37:17ZengMDPI AGCancers2072-66942021-03-01135116310.3390/cancers13051163Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck CancerFoteinos-Ioannis Dimitrakopoulos0Georgia-Angeliki Koliou1Vassiliki Kotoula2Kyriaki Papadopoulou3Konstantinos Markou4Konstantinos Vlachtsis5Nikolaos Angouridakis6Ilias Karasmanis7Angelos Nikolaou8Amanda Psyrri9Anastasios Visvikis10Paris Kosmidis11George Fountzilas12Angelos Koutras13Division of Oncology & Molecular Oncology Laboratory, Department of Medicine, University Hospital, Medical School, University of Patras, 26504 Patras, GreeceSection of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, 11526 Athens, GreeceDepartment of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, 54006 Thessaloniki, GreeceLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, GreeceSecond Academic Otorhinolaryngology-Head and Neck Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloníki, GreeceOtolaryngology Department, G. Papanikolaou General Hospital, 57010 Thessaloniki, GreeceSecond Academic Otorhinolaryngology-Head and Neck Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloníki, GreeceOtolaryngology Department, G. Papanikolaou General Hospital, 57010 Thessaloniki, GreeceOtolaryngology Department, G. Papanikolaou General Hospital, 57010 Thessaloniki, GreeceDepartment of Internal Medicine, Section of Medical Oncology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceThird Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece, <email>hecogaga@otenet.gr</email>Second Department of Medical Oncology, Hygeia Hospital, 15123 Athens, GreeceLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, GreeceDivision of Oncology & Molecular Oncology Laboratory, Department of Medicine, University Hospital, Medical School, University of Patras, 26504 Patras, GreeceHead and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes (<i>VEGFA</i>, <i>FAS</i>, <i>EDNRA</i> and <i>NBS1</i>) were evaluated regarding their clinical significance in HNC patients. In total, 333 HNC patients were enrolled in this study and 34 variants located on the aforementioned genes were genotyped via Sanger sequencing. LC patients, homozygous A for <i>VEGFA</i> rs13207351, had shorter overall survival (OS) as opposed to homozygous G (Hazard ratio (HR) = 2.06, Wald’s <i>p =</i> 0.017) upon adjustment for age, disease stage, and surgery. Following the dominant model, LC patients carrying the A allele had a marginally significantly higher risk for death (HR = 1.72, <i>p</i> = 0.059). NPC patients heterozygous (CT) for <i>FAS</i> rs2234768 had a marginal but significantly higher risk of death compared to those with homozygosity for the T allele (HR = 2.22, <i>p</i> = 0.056). In conclusion, rs13207351 (<i>VEGFA</i>) and rs2234768 (<i>FAS</i>) polymorphisms seem to have prognostic significance in HNC, with <i>VEGFA</i> rs13207351 showing the most promise in this subgroup of LC patients.https://www.mdpi.com/2072-6694/13/5/1163head and neck cancernasopharyngeal cancerVEGFAFASendothelinNBS1 |
| spellingShingle | Foteinos-Ioannis Dimitrakopoulos Georgia-Angeliki Koliou Vassiliki Kotoula Kyriaki Papadopoulou Konstantinos Markou Konstantinos Vlachtsis Nikolaos Angouridakis Ilias Karasmanis Angelos Nikolaou Amanda Psyrri Anastasios Visvikis Paris Kosmidis George Fountzilas Angelos Koutras Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer Cancers head and neck cancer nasopharyngeal cancer VEGFA FAS endothelin NBS1 |
| title | Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer |
| title_full | Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer |
| title_fullStr | Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer |
| title_full_unstemmed | Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer |
| title_short | Genetic Variation in the <i>Vascular Endothelial Growth Factor (VEGFA</i>) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer |
| title_sort | genetic variation in the i vascular endothelial growth factor vegfa i gene at rs13207351 is associated with overall survival of patients with head and neck cancer |
| topic | head and neck cancer nasopharyngeal cancer VEGFA FAS endothelin NBS1 |
| url | https://www.mdpi.com/2072-6694/13/5/1163 |
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