PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04766-9 |
| _version_ | 1818751655344078848 |
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| author | Jessica van Setten Jennifer A. Brody Yalda Jamshidi Brenton R. Swenson Anne M. Butler Harry Campbell Fabiola M. Del Greco Daniel S. Evans Quince Gibson Daniel F. Gudbjartsson Kathleen F. Kerr Bouwe P. Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M. Nolte Sandosh Padmanabhan Marylyn D. Ritchie Antonietta Robino Albert V. Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O. Arnar Folkert W. Asselbergs Joel S. Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M. Buckley Mina K. Chung Dana Crawford Marcel den Hoed Josh C. Denny Anna F. Dominiczak Georg B. Ehret Mark Eijgelsheim Patrick T. Ellinor Stephan B. Felix Oscar H. Franco Lude Franke Tamara B. Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A. Kors Edward G. Lakatta Lenore J. Launer Honghuang Lin Henry J. Lin Ruth J. F. Loos Steven A. Lubitz Peter W. Macfarlane Jared W. Magnani Irene Mateo Leach Thomas Meitinger Braxton D. Mitchell Thomas Munzel George J. Papanicolaou Annette Peters Arne Pfeufer Peter P. Pramstaller Olli T. Raitakari Jerome I. Rotter Igor Rudan Nilesh J. Samani David Schlessinger Claudia T. Silva Aldana Moritz F. Sinner Jonathan D. Smith Harold Snieder Elsayed Z. Soliman Timothy D. Spector David J. Stott Konstantin Strauch Kirill V. Tarasov Unnur Thorsteinsdottir Andre G. Uitterlinden David R. Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S. Wild Tanja Zeller Alvaro Alonso Christy L. Avery Stefania Bandinelli Emelia J. Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R. Heckbert Andrew A. Hicks J. Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B. Munroe Afshin Parsa Ozren Polasek Bruce M. Psaty Dan M. Roden Renate B. Schnabel Gianfranco Sinagra Kari Stefansson Bruno H. Stricker Pim van der Harst Cornelia M. van Duijn James F. Wilson Sina A. Gharib Paul I. W. de Bakker Aaron Isaacs Dan E. Arking Nona Sotoodehnia |
| author_facet | Jessica van Setten Jennifer A. Brody Yalda Jamshidi Brenton R. Swenson Anne M. Butler Harry Campbell Fabiola M. Del Greco Daniel S. Evans Quince Gibson Daniel F. Gudbjartsson Kathleen F. Kerr Bouwe P. Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M. Nolte Sandosh Padmanabhan Marylyn D. Ritchie Antonietta Robino Albert V. Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O. Arnar Folkert W. Asselbergs Joel S. Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M. Buckley Mina K. Chung Dana Crawford Marcel den Hoed Josh C. Denny Anna F. Dominiczak Georg B. Ehret Mark Eijgelsheim Patrick T. Ellinor Stephan B. Felix Oscar H. Franco Lude Franke Tamara B. Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A. Kors Edward G. Lakatta Lenore J. Launer Honghuang Lin Henry J. Lin Ruth J. F. Loos Steven A. Lubitz Peter W. Macfarlane Jared W. Magnani Irene Mateo Leach Thomas Meitinger Braxton D. Mitchell Thomas Munzel George J. Papanicolaou Annette Peters Arne Pfeufer Peter P. Pramstaller Olli T. Raitakari Jerome I. Rotter Igor Rudan Nilesh J. Samani David Schlessinger Claudia T. Silva Aldana Moritz F. Sinner Jonathan D. Smith Harold Snieder Elsayed Z. Soliman Timothy D. Spector David J. Stott Konstantin Strauch Kirill V. Tarasov Unnur Thorsteinsdottir Andre G. Uitterlinden David R. Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S. Wild Tanja Zeller Alvaro Alonso Christy L. Avery Stefania Bandinelli Emelia J. Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R. Heckbert Andrew A. Hicks J. Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B. Munroe Afshin Parsa Ozren Polasek Bruce M. Psaty Dan M. Roden Renate B. Schnabel Gianfranco Sinagra Kari Stefansson Bruno H. Stricker Pim van der Harst Cornelia M. van Duijn James F. Wilson Sina A. Gharib Paul I. W. de Bakker Aaron Isaacs Dan E. Arking Nona Sotoodehnia |
| author_sort | Jessica van Setten |
| collection | DOAJ |
| description | Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation. |
| first_indexed | 2024-12-18T04:39:01Z |
| format | Article |
| id | doaj.art-df5945ec05b64c95b22859c1f2918530 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:39:01Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-df5945ec05b64c95b22859c1f29185302022-12-21T21:20:47ZengNature PortfolioNature Communications2041-17232018-07-019111110.1038/s41467-018-04766-9PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activityJessica van Setten0Jennifer A. Brody1Yalda Jamshidi2Brenton R. Swenson3Anne M. Butler4Harry Campbell5Fabiola M. Del Greco6Daniel S. Evans7Quince Gibson8Daniel F. Gudbjartsson9Kathleen F. Kerr10Bouwe P. Krijthe11Leo-Pekka Lyytikäinen12Christian Müller13Martina Müller-Nurasyid14Ilja M. Nolte15Sandosh Padmanabhan16Marylyn D. Ritchie17Antonietta Robino18Albert V. Smith19Maristella Steri20Toshiko Tanaka21Alexander Teumer22Stella Trompet23Sheila Ulivi24Niek Verweij25Xiaoyan Yin26David O. Arnar27Folkert W. Asselbergs28Joel S. Bader29John Barnard30Josh Bis31Stefan Blankenberg32Eric Boerwinkle33Yuki Bradford34Brendan M. Buckley35Mina K. Chung36Dana Crawford37Marcel den Hoed38Josh C. Denny39Anna F. Dominiczak40Georg B. Ehret41Mark Eijgelsheim42Patrick T. Ellinor43Stephan B. Felix44Oscar H. Franco45Lude Franke46Tamara B. Harris47Hilma Holm48Gandin Ilaria49Annamaria Iorio50Mika Kähönen51Ivana Kolcic52Jan A. Kors53Edward G. Lakatta54Lenore J. Launer55Honghuang Lin56Henry J. Lin57Ruth J. F. Loos58Steven A. Lubitz59Peter W. Macfarlane60Jared W. Magnani61Irene Mateo Leach62Thomas Meitinger63Braxton D. Mitchell64Thomas Munzel65George J. Papanicolaou66Annette Peters67Arne Pfeufer68Peter P. Pramstaller69Olli T. Raitakari70Jerome I. Rotter71Igor Rudan72Nilesh J. Samani73David Schlessinger74Claudia T. Silva Aldana75Moritz F. Sinner76Jonathan D. Smith77Harold Snieder78Elsayed Z. Soliman79Timothy D. Spector80David J. Stott81Konstantin Strauch82Kirill V. Tarasov83Unnur Thorsteinsdottir84Andre G. Uitterlinden85David R. Van Wagoner86Uwe Völker87Henry Völzke88Melanie Waldenberger89Harm Jan Westra90Philipp S. Wild91Tanja Zeller92Alvaro Alonso93Christy L. Avery94Stefania Bandinelli95Emelia J. Benjamin96Francesco Cucca97Marcus Dörr98Luigi Ferrucci99Paolo Gasparini100Vilmundur Gudnason101Caroline Hayward102Susan R. Heckbert103Andrew A. Hicks104J. Wouter Jukema105Stefan Kääb106Terho Lehtimäki107Yongmei Liu108Patricia B. Munroe109Afshin Parsa110Ozren Polasek111Bruce M. Psaty112Dan M. Roden113Renate B. Schnabel114Gianfranco Sinagra115Kari Stefansson116Bruno H. Stricker117Pim van der Harst118Cornelia M. van Duijn119James F. Wilson120Sina A. Gharib121Paul I. W. de Bakker122Aaron Isaacs123Dan E. Arking124Nona Sotoodehnia125Department of Cardiology, University Medical Center Utrecht, University of UtrechtDepartment of Medicine, Cardiovascular Health Research Unit, University of WashingtonCardiogenetics Lab, Molecular and Clinical Sciences Research Institute, St George’s University of LondonDepartment of Medicine, Cardiovascular Health Research Unit, University of WashingtonDivision of Infectious Diseases, Washington University School of MedicineCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of EdinburghInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of LübeckCalifornia Pacific Medical Center Research InstituteDepartment of Surgery, University of Alabama Birmingham HospitaldeCODE genetics/Amgen, Inc.Department of Biostatistics, School of Public Health, University of WashingtonDepartment of Epidemiology, Erasmus Medical CenterDepartment of Clinical Chemistry, Fimlab LaboratoriesDepartment of General and Interventional Cardiology, University Heart Center Hamburg-EppendorfInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental HealthDepartment of Epidemiology, University of Groningen, University Medical Center GroningenInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Genetics, University of PennsylvaniaInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”Icelandic Heart AssociationIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR)Translational Gerontology Branch, NIAInstitute for Community Medicine, University Medicine GreifswaldDepartment of Cardiology, Leiden University Medical CenterInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”Department of Cardiology, University Medical Center Groningen, University of GroningenDepartment of Medicine, Boston University School of MedicinedeCODE genetics/Amgen, Inc.Department of Cardiology, University Medical Center Utrecht, University of UtrechtDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland ClinicDepartment of General and Interventional Cardiology, University Heart Center Hamburg-EppendorfDZHK (German Center for Cardiovascular Research) Partner SiteHuman Genetics Center, University of Texas Health Science Center at HoustonDepartment of Genetics, University of PennsylvaniaDepartment of Pharmacology and Therapeutics, University College CorkDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland ClinicInstitute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Immunology, Genetics and Pathology, Uppsala UniversityBiomedical Informatics and Medicine, Vanderbilt UniversityInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of MedicineDepartment of Epidemiology, Erasmus Medical CenterProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardDZHK (German Centre for Cardiovascular Research), Partner Site GreifswaldDepartment of Epidemiology, Erasmus Medical CenterDepartment of Genetics, University of Groningen, University Medical Center GroningenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of HealthdeCODE genetics/Amgen, Inc.Department of Medical Sciences, University of TriesteCardiovascular Department, “Ospedali Riuniti and University of Trieste”Department of Clinical Physiology, Tampere University HospitalFaculty of Medicine, University of SplitDepartment of Medical Informatics, Erasmus University Medical CenterLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of HealthLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of HealthDepartment of Medicine, Boston University School of MedicineThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardInstitute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Medicine, Division of Cardiology, University of Pittsburgh Medical Center Heart and Vascular Institute, University of PittsburghDepartment of Cardiology, University Medical Center Groningen, University of GroningenDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart AllianceDepartment of Medicine, University of Maryland School of Medicine, Geriatrics Research and Education Clinical Center, Baltimore VA Medical CenterCenter for Cardiology, University Medical Center of the Johannes Gutenberg-University MainzDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIHDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart AllianceMVZ für MolekulardiagnostikInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of LübeckDepartment of Clinical Physiology and Nuclear Medicine, Turku University HospitalDepartments of Medicine and Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of EdinburghDepartment of Cardiovascular Sciences, University of LeicesterLaboratory of Genetics and Genomics, National Institute on Aging, National Institute of HealthGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical CenterDepartment of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) MunichDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland ClinicDepartment of Epidemiology, University of Groningen, University Medical Center GroningenEpidemiological Cardiology Research Center, Wake Forest School of MedicineDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital, King’s College LondonInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental HealthLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of HealthdeCODE genetics/Amgen, Inc.Department of Internal Medicine, Erasmus Medical CenterDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland ClinicDZHK (German Centre for Cardiovascular Research), Partner Site GreifswaldInstitute for Community Medicine, University Medicine GreifswaldDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart AllianceDepartment of Genetics, University of Groningen, University Medical Center GroningenDZHK (German Center for Cardiovascular Research), Partner Site Rhine-MainDepartment of General and Interventional Cardiology, University Heart Center Hamburg-EppendorfDepartment of Epidemiology, Rollins School of Public Health, Emory UniversityDepartment of Epidemiology and Carolina Population Center, University of North Carolina at Chapel HillGeriatric Unit, Azienda Sanitaria Firenze (ASF)Durrer Center for Cardiogenetic Research, Netherlands Heart InstituteIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR)DZHK (German Centre for Cardiovascular Research), Partner Site GreifswaldTranslational Gerontology Branch, NIAInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”Icelandic Heart AssociationMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghCardiovascular Health Research Unit and the Department of Epidemiology, University of WashingtonInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of LübeckDepartment of Cardiology, Leiden University Medical CenterDepartment of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) MunichDepartment of Clinical Chemistry, Fimlab LaboratoriesDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest UniversityClinical Pharmacology, William Harvey Research Institute, Queen Mary University of LondonDepartment of Medicine, University of Maryland School of Medicine and Baltimore VA Medical CenterFaculty of Medicine, University of SplitCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of WashingtonMedicine, Pharmacology, and Biomedical Informatics, Vanderbilt UniversityDepartment of General and Interventional Cardiology, University Heart Center Hamburg-EppendorfCardiovascular Department, “Ospedali Riuniti and University of Trieste”deCODE genetics/Amgen, Inc.Department of Epidemiology, Erasmus Medical CenterDepartment of Cardiology, University Medical Center Groningen, University of GroningenGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical CenterCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of EdinburghCardiovascular Health Research Unit, Division of Pulmonary Critical Care and Sleep Medicine, Computational Medicine Core at Center for Lung Biology, Department of Medicine, University of WashingtonDepartment of Genetics, Center for Molecular Medicine, University Medical Center UtrechtCARIM School for Cardiovascular DiseasesMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of MedicineDepartments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of WashingtonAbnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation.https://doi.org/10.1038/s41467-018-04766-9 |
| spellingShingle | Jessica van Setten Jennifer A. Brody Yalda Jamshidi Brenton R. Swenson Anne M. Butler Harry Campbell Fabiola M. Del Greco Daniel S. Evans Quince Gibson Daniel F. Gudbjartsson Kathleen F. Kerr Bouwe P. Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M. Nolte Sandosh Padmanabhan Marylyn D. Ritchie Antonietta Robino Albert V. Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O. Arnar Folkert W. Asselbergs Joel S. Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M. Buckley Mina K. Chung Dana Crawford Marcel den Hoed Josh C. Denny Anna F. Dominiczak Georg B. Ehret Mark Eijgelsheim Patrick T. Ellinor Stephan B. Felix Oscar H. Franco Lude Franke Tamara B. Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A. Kors Edward G. Lakatta Lenore J. Launer Honghuang Lin Henry J. Lin Ruth J. F. Loos Steven A. Lubitz Peter W. Macfarlane Jared W. Magnani Irene Mateo Leach Thomas Meitinger Braxton D. Mitchell Thomas Munzel George J. Papanicolaou Annette Peters Arne Pfeufer Peter P. Pramstaller Olli T. Raitakari Jerome I. Rotter Igor Rudan Nilesh J. Samani David Schlessinger Claudia T. Silva Aldana Moritz F. Sinner Jonathan D. Smith Harold Snieder Elsayed Z. Soliman Timothy D. Spector David J. Stott Konstantin Strauch Kirill V. Tarasov Unnur Thorsteinsdottir Andre G. Uitterlinden David R. Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S. Wild Tanja Zeller Alvaro Alonso Christy L. Avery Stefania Bandinelli Emelia J. Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R. Heckbert Andrew A. Hicks J. Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B. Munroe Afshin Parsa Ozren Polasek Bruce M. Psaty Dan M. Roden Renate B. Schnabel Gianfranco Sinagra Kari Stefansson Bruno H. Stricker Pim van der Harst Cornelia M. van Duijn James F. Wilson Sina A. Gharib Paul I. W. de Bakker Aaron Isaacs Dan E. Arking Nona Sotoodehnia PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity Nature Communications |
| title | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| title_full | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| title_fullStr | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| title_full_unstemmed | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| title_short | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| title_sort | pr interval genome wide association meta analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
| url | https://doi.org/10.1038/s41467-018-04766-9 |
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