Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry)
Background Multiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report the changes in the epidemiology of patients with CVT mana...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
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| Series: | Stroke and Vascular Neurology |
| Online Access: | https://svn.bmj.com/content/early/2023/08/22/svn-2023-002351.full |
| _version_ | 1827861654205890560 |
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| author | Vivek Mathew Mahasampath Gowri Sanjith Aaron Ajith Sivadasan George Abraham Ninan Rohit N Benjamin Appaswamy Thirumal Prabhakar Angel Miraclin T John Davis Prasad Deepti Bal Atif Iqbal Ahmed Shaikh |
| author_facet | Vivek Mathew Mahasampath Gowri Sanjith Aaron Ajith Sivadasan George Abraham Ninan Rohit N Benjamin Appaswamy Thirumal Prabhakar Angel Miraclin T John Davis Prasad Deepti Bal Atif Iqbal Ahmed Shaikh |
| author_sort | Vivek Mathew |
| collection | DOAJ |
| description | Background Multiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report the changes in the epidemiology of patients with CVT managed over the past 26 years.Methods The CMC Vellore CVT registry is a prospectively maintained database at the Christian Medical College, Vellore since January 1995. Stata software was used to analyse the data and assess the changes in the incidence, age and gender distribution over the previous 26 years.Results Among 1701 patients treated during the study period, 908 (53%) were women and 793 (47%) were men. The mean incidence of CVT was 49 per 100 000 admissions before 2010, which increased to 96 per 100 000 after 2010. Male gender had a higher odds of developing CVT (OR – 2.07 (CI 1.68 to 2.55, p<0.001). This could be attributed to the declining incidence of postpartum CVT after 2010 compared with the decade before 2010 (50% vs 20%). The mean age at presentation had increased from 24.5 to 33.2 years in the last decade.Conclusions There was a clear change in the gender pattern from being a condition with female preponderance, to one where equal or more men are being affected. Lower incidence of postpartum CVT cases could be the driving factor. An increase in the overall incidence of CVT cases was noted, probably due to a higher index of clinical suspicion and better diagnostic imaging modalities. |
| first_indexed | 2024-03-12T13:41:38Z |
| format | Article |
| id | doaj.art-df5a10bb5ad34566a6d67ac792a5fa56 |
| institution | Directory Open Access Journal |
| issn | 2059-8696 |
| language | English |
| last_indexed | 2024-03-12T13:41:38Z |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Stroke and Vascular Neurology |
| spelling | doaj.art-df5a10bb5ad34566a6d67ac792a5fa562023-08-23T16:00:08ZengBMJ Publishing GroupStroke and Vascular Neurology2059-869610.1136/svn-2023-002351Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry)Vivek Mathew0Mahasampath Gowri1Sanjith Aaron2Ajith Sivadasan3George Abraham Ninan4Rohit N Benjamin5Appaswamy Thirumal Prabhakar6Angel Miraclin T7John Davis Prasad8Deepti Bal9Atif Iqbal Ahmed Shaikh10Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Biostatistics, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, IndiaDepartment of Neurosciences, Christian Medical College Vellore, Vellore, Tamil Nadu, IndiaDepartment of Neurosciences, Christian Medical College Vellore, Vellore, Tamil Nadu, IndiaNeurology, Christian Medical College Vellore, Vellore, Tamil Nadu, IndiaDepartment of Neurosciences, Christian Medical College Vellore, Vellore, Tamil Nadu, IndiaDepartment of Neurosciences, Christian Medical College Vellore, Vellore, Tamil Nadu, IndiaDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, IndiaBackground Multiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report the changes in the epidemiology of patients with CVT managed over the past 26 years.Methods The CMC Vellore CVT registry is a prospectively maintained database at the Christian Medical College, Vellore since January 1995. Stata software was used to analyse the data and assess the changes in the incidence, age and gender distribution over the previous 26 years.Results Among 1701 patients treated during the study period, 908 (53%) were women and 793 (47%) were men. The mean incidence of CVT was 49 per 100 000 admissions before 2010, which increased to 96 per 100 000 after 2010. Male gender had a higher odds of developing CVT (OR – 2.07 (CI 1.68 to 2.55, p<0.001). This could be attributed to the declining incidence of postpartum CVT after 2010 compared with the decade before 2010 (50% vs 20%). The mean age at presentation had increased from 24.5 to 33.2 years in the last decade.Conclusions There was a clear change in the gender pattern from being a condition with female preponderance, to one where equal or more men are being affected. Lower incidence of postpartum CVT cases could be the driving factor. An increase in the overall incidence of CVT cases was noted, probably due to a higher index of clinical suspicion and better diagnostic imaging modalities.https://svn.bmj.com/content/early/2023/08/22/svn-2023-002351.full |
| spellingShingle | Vivek Mathew Mahasampath Gowri Sanjith Aaron Ajith Sivadasan George Abraham Ninan Rohit N Benjamin Appaswamy Thirumal Prabhakar Angel Miraclin T John Davis Prasad Deepti Bal Atif Iqbal Ahmed Shaikh Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) Stroke and Vascular Neurology |
| title | Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) |
| title_full | Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) |
| title_fullStr | Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) |
| title_full_unstemmed | Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) |
| title_short | Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) |
| title_sort | cerebral venous sinus thrombosis changing trends in the incidence age and gender findings from the cmc vellore cvt registry |
| url | https://svn.bmj.com/content/early/2023/08/22/svn-2023-002351.full |
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