Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability
In recent years, multifunctional hydrogels have received a great deal of attention because they are biocompatible and can mimic the extracellular matrix. Herein, we prepared hydrogels of biocompatible cross-linked networks with photothermal properties. In this study, a chitosan/polyaniline/laponite...
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1089 |
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| author | Liying Zhang Gao He Yang Yu Yu Zhang Xiang Li Shige Wang |
| author_facet | Liying Zhang Gao He Yang Yu Yu Zhang Xiang Li Shige Wang |
| author_sort | Liying Zhang |
| collection | DOAJ |
| description | In recent years, multifunctional hydrogels have received a great deal of attention because they are biocompatible and can mimic the extracellular matrix. Herein, we prepared hydrogels of biocompatible cross-linked networks with photothermal properties. In this study, a chitosan/polyaniline/laponite (COL) hydrogel with photothermal conversion capability was designed. Polyaniline was firstly grafted onto chitosan and its solution was mixed with oxidized dextran, which was then cross-linked into a hydrogel via a Schiff base reaction. Furthermore, an aluminosilicate clay material, laponite (LAP), was incorporated into the hydrogel. The swelling ratio of the COL hydrogel in various solutions was greater than 580%, and it showed good degradation ability (the mass–loss ratio was over 45% after 28 days). This composite hydrogel was demonstrated to have good photothermal conversion properties and biocompatibility at both the cell (cell viability was over 97%) and animal levels. The COL hydrogel showed a photothermal conversion efficiency of 23.7% under the irradiation of a near-infrared laser. Coupled with the osteogenic differentiation-inducing potential of LAP, the COL hydrogel has the potential to kill tumors via hyperthermia or serve as scaffolds for bone tissue regeneration. |
| first_indexed | 2024-03-09T04:40:28Z |
| format | Article |
| id | doaj.art-df5a344e4daa4f229a72bfc1d7ead930 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T04:40:28Z |
| publishDate | 2022-08-01 |
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| series | Biomolecules |
| spelling | doaj.art-df5a344e4daa4f229a72bfc1d7ead9302023-12-03T13:22:45ZengMDPI AGBiomolecules2218-273X2022-08-01128108910.3390/biom12081089Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion CapabilityLiying Zhang0Gao He1Yang Yu2Yu Zhang3Xiang Li4Shige Wang5School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaThe First Clinial Medical College, Nanjing Medical University, No. 101 Longmian Road, Nanjing 211166, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaThe First Clinial Medical College, Nanjing Medical University, No. 101 Longmian Road, Nanjing 211166, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaIn recent years, multifunctional hydrogels have received a great deal of attention because they are biocompatible and can mimic the extracellular matrix. Herein, we prepared hydrogels of biocompatible cross-linked networks with photothermal properties. In this study, a chitosan/polyaniline/laponite (COL) hydrogel with photothermal conversion capability was designed. Polyaniline was firstly grafted onto chitosan and its solution was mixed with oxidized dextran, which was then cross-linked into a hydrogel via a Schiff base reaction. Furthermore, an aluminosilicate clay material, laponite (LAP), was incorporated into the hydrogel. The swelling ratio of the COL hydrogel in various solutions was greater than 580%, and it showed good degradation ability (the mass–loss ratio was over 45% after 28 days). This composite hydrogel was demonstrated to have good photothermal conversion properties and biocompatibility at both the cell (cell viability was over 97%) and animal levels. The COL hydrogel showed a photothermal conversion efficiency of 23.7% under the irradiation of a near-infrared laser. Coupled with the osteogenic differentiation-inducing potential of LAP, the COL hydrogel has the potential to kill tumors via hyperthermia or serve as scaffolds for bone tissue regeneration.https://www.mdpi.com/2218-273X/12/8/1089hydrogelchitosanpolyanilinephotothermalbiocompatibility |
| spellingShingle | Liying Zhang Gao He Yang Yu Yu Zhang Xiang Li Shige Wang Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability Biomolecules hydrogel chitosan polyaniline photothermal biocompatibility |
| title | Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability |
| title_full | Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability |
| title_fullStr | Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability |
| title_full_unstemmed | Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability |
| title_short | Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability |
| title_sort | design of biocompatible chitosan polyaniline laponite hydrogel with photothermal conversion capability |
| topic | hydrogel chitosan polyaniline photothermal biocompatibility |
| url | https://www.mdpi.com/2218-273X/12/8/1089 |
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