Neocerebellar contributions to social perception in adolescents with autism spectrum disorder
Posterior superior temporal sulcus (pSTS) is specialized for interpreting perceived human actions, and disruptions to its function occur in autism spectrum disorder (ASD). Here we consider the role of Crus I of neocerebellum in supporting pSTS function. Research has associated Crus I activity with i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929314000528 |
| _version_ | 1819048745918005248 |
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| author | Allison Jack James P. Morris |
| author_facet | Allison Jack James P. Morris |
| author_sort | Allison Jack |
| collection | DOAJ |
| description | Posterior superior temporal sulcus (pSTS) is specialized for interpreting perceived human actions, and disruptions to its function occur in autism spectrum disorder (ASD). Here we consider the role of Crus I of neocerebellum in supporting pSTS function. Research has associated Crus I activity with imitation and biological motion perception, and neocerebellum is theorized to coordinate activity among cerebral sites more generally. Moreover, cerebellar abnormalities have been associated with ASD. We hypothesized that disordered Crus I–pSTS interactions could predict social deficits in ASD. 15 high functioning adolescents with ASD and 15 same-age comparison youth participated in an fMRI imitation paradigm; ratings of mentalizing ability were collected via parent report. We predicted that stronger Crus I–pSTS interactions would be associated with better mentalizing ability. Consistent with these hypotheses, stronger psychophysiological interactions between Crus I and right pSTS were associated with greater mentalizing ability among adolescents with ASD. Whole-brain analyses also indicated that typically developing youth recruited right inferior frontal gyrus, left pSTS, medial occipital regions, and precuneus more strongly during imitation than did youth with ASD. Overall, these results indicate that variability in neocerebellar interactions with key cortical social brain sites may help explain individual differences in social perceptual outcomes in ASD. |
| first_indexed | 2024-12-21T11:21:09Z |
| format | Article |
| id | doaj.art-df5dc2636dc847119e765fd26b76bff9 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-21T11:21:09Z |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-df5dc2636dc847119e765fd26b76bff92022-12-21T19:05:46ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072014-10-0110C779210.1016/j.dcn.2014.08.001Neocerebellar contributions to social perception in adolescents with autism spectrum disorderAllison JackJames P. MorrisPosterior superior temporal sulcus (pSTS) is specialized for interpreting perceived human actions, and disruptions to its function occur in autism spectrum disorder (ASD). Here we consider the role of Crus I of neocerebellum in supporting pSTS function. Research has associated Crus I activity with imitation and biological motion perception, and neocerebellum is theorized to coordinate activity among cerebral sites more generally. Moreover, cerebellar abnormalities have been associated with ASD. We hypothesized that disordered Crus I–pSTS interactions could predict social deficits in ASD. 15 high functioning adolescents with ASD and 15 same-age comparison youth participated in an fMRI imitation paradigm; ratings of mentalizing ability were collected via parent report. We predicted that stronger Crus I–pSTS interactions would be associated with better mentalizing ability. Consistent with these hypotheses, stronger psychophysiological interactions between Crus I and right pSTS were associated with greater mentalizing ability among adolescents with ASD. Whole-brain analyses also indicated that typically developing youth recruited right inferior frontal gyrus, left pSTS, medial occipital regions, and precuneus more strongly during imitation than did youth with ASD. Overall, these results indicate that variability in neocerebellar interactions with key cortical social brain sites may help explain individual differences in social perceptual outcomes in ASD.http://www.sciencedirect.com/science/article/pii/S1878929314000528Autism spectrum disordersCerebellumImitationEffective connectivityMentalizingSuperior temporal sulcus |
| spellingShingle | Allison Jack James P. Morris Neocerebellar contributions to social perception in adolescents with autism spectrum disorder Developmental Cognitive Neuroscience Autism spectrum disorders Cerebellum Imitation Effective connectivity Mentalizing Superior temporal sulcus |
| title | Neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| title_full | Neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| title_fullStr | Neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| title_full_unstemmed | Neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| title_short | Neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| title_sort | neocerebellar contributions to social perception in adolescents with autism spectrum disorder |
| topic | Autism spectrum disorders Cerebellum Imitation Effective connectivity Mentalizing Superior temporal sulcus |
| url | http://www.sciencedirect.com/science/article/pii/S1878929314000528 |
| work_keys_str_mv | AT allisonjack neocerebellarcontributionstosocialperceptioninadolescentswithautismspectrumdisorder AT jamespmorris neocerebellarcontributionstosocialperceptioninadolescentswithautismspectrumdisorder |