Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
Background: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the ef...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Ginseng Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845314000876 |
| _version_ | 1819067800619057152 |
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| author | Chi-Yeon Lim Jeong-Min Moon Bu-Yeo Kim Se-Hyun Lim Guem-San Lee Hak-Sun Yu Su-In Cho |
| author_facet | Chi-Yeon Lim Jeong-Min Moon Bu-Yeo Kim Se-Hyun Lim Guem-San Lee Hak-Sun Yu Su-In Cho |
| author_sort | Chi-Yeon Lim |
| collection | DOAJ |
| description | Background: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma.
Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined.
Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVA-sensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls.
Conclusion: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG. |
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| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-12-21T16:24:01Z |
| publishDate | 2015-01-01 |
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| series | Journal of Ginseng Research |
| spelling | doaj.art-df5f912e7dd34e99a0b1abe6d23e18902022-12-21T18:57:29ZengElsevierJournal of Ginseng Research1226-84532015-01-01391384510.1016/j.jgr.2014.07.004Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in miceChi-Yeon Lim0Jeong-Min Moon1Bu-Yeo Kim2Se-Hyun Lim3Guem-San Lee4Hak-Sun Yu5Su-In Cho6College of Medicine, Dongguk University, Ilsan, Gyeonggi-do, KoreaSchool of Korean Medicine, Pusan National University, Yangsan, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, KoreaSchool of Public Health, Far East University, Chungbuk, KoreaCollege of Korean Medicine, Wonkwang University, Iksan, Jeonbuk, KoreaDepartment of Parasitology, School of Medicine, Pusan National University, Yangsan, KoreaSchool of Korean Medicine, Pusan National University, Yangsan, KoreaBackground: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma. Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined. Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVA-sensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls. Conclusion: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.http://www.sciencedirect.com/science/article/pii/S1226845314000876asthmaKorean ginsengred ginsengwhite ginseng |
| spellingShingle | Chi-Yeon Lim Jeong-Min Moon Bu-Yeo Kim Se-Hyun Lim Guem-San Lee Hak-Sun Yu Su-In Cho Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice Journal of Ginseng Research asthma Korean ginseng red ginseng white ginseng |
| title | Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice |
| title_full | Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice |
| title_fullStr | Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice |
| title_full_unstemmed | Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice |
| title_short | Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice |
| title_sort | comparative study of korean white ginseng and korean red ginseng on efficacies of ova induced asthma model in mice |
| topic | asthma Korean ginseng red ginseng white ginseng |
| url | http://www.sciencedirect.com/science/article/pii/S1226845314000876 |
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