Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy
Abstract Background Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-020-00838-4 |
| _version_ | 1818668371662602240 |
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| author | Xueying Huang Long Deng Heng Zuo Chun Yang Yunhu Song Mary Lesperance Dalin Tang |
| author_facet | Xueying Huang Long Deng Heng Zuo Chun Yang Yunhu Song Mary Lesperance Dalin Tang |
| author_sort | Xueying Huang |
| collection | DOAJ |
| description | Abstract Background Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Conclusion Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM. |
| first_indexed | 2024-12-17T06:35:16Z |
| format | Article |
| id | doaj.art-df60703c4f0f46d49591b2364deb8289 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-17T06:35:16Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-df60703c4f0f46d49591b2364deb82892022-12-21T22:00:01ZengBMCBioMedical Engineering OnLine1475-925X2021-01-0120111510.1186/s12938-020-00838-4Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathyXueying Huang0Long Deng1Heng Zuo2Chun Yang3Yunhu Song4Mary Lesperance5Dalin Tang6School of Mathematical Sciences, Xiamen UniversityDepartment of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical SciencesSchool of Mathematical Sciences, Sichuan Normal UniversityMathematical Sciences Department, Worcester Polytechnic InstituteDepartment of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical SciencesDepartment of Mathematics and Statistics, University of VictoriaMathematical Sciences Department, Worcester Polytechnic InstituteAbstract Background Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Conclusion Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM.https://doi.org/10.1186/s12938-020-00838-4Fluid–structure interactionsLeft ventricleMitral valveSystolic anterior motionPassive computational modelActive computational model |
| spellingShingle | Xueying Huang Long Deng Heng Zuo Chun Yang Yunhu Song Mary Lesperance Dalin Tang Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy BioMedical Engineering OnLine Fluid–structure interactions Left ventricle Mitral valve Systolic anterior motion Passive computational model Active computational model |
| title | Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| title_full | Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| title_fullStr | Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| title_full_unstemmed | Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| title_short | Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| title_sort | comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy |
| topic | Fluid–structure interactions Left ventricle Mitral valve Systolic anterior motion Passive computational model Active computational model |
| url | https://doi.org/10.1186/s12938-020-00838-4 |
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