New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies
Cardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1390 |
| _version_ | 1797445235384516608 |
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| author | Yuanyuan Zhao Dunfeng Du Shanshan Chen Zhishui Chen Jiajia Zhao |
| author_facet | Yuanyuan Zhao Dunfeng Du Shanshan Chen Zhishui Chen Jiajia Zhao |
| author_sort | Yuanyuan Zhao |
| collection | DOAJ |
| description | Cardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associated with pathological myocardial remodeling, characterized by the excessive deposition of extracellular matrix (ECM) proteins in cardiac parenchymal tissues. In recent years, a growing body of evidence demonstrated that microRNAs (miRNAs) have a crucial role in the pathological development of cardiac fibrosis. More than sixty miRNAs have been associated with the progression of cardiac fibrosis. In this review, we summarized potential miRNAs and miRNAs-related regulatory mechanisms for cardiac fibrosis and discussed the potential clinical application of miRNAs in cardiac fibrosis. |
| first_indexed | 2024-03-09T13:22:51Z |
| format | Article |
| id | doaj.art-df607d9aadba438f906c627001c0a1b0 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T13:22:51Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-df607d9aadba438f906c627001c0a1b02023-11-30T21:27:43ZengMDPI AGGenes2073-44252022-08-01138139010.3390/genes13081390New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic StrategiesYuanyuan Zhao0Dunfeng Du1Shanshan Chen2Zhishui Chen3Jiajia Zhao4Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaKey Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, ChinaInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaCardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associated with pathological myocardial remodeling, characterized by the excessive deposition of extracellular matrix (ECM) proteins in cardiac parenchymal tissues. In recent years, a growing body of evidence demonstrated that microRNAs (miRNAs) have a crucial role in the pathological development of cardiac fibrosis. More than sixty miRNAs have been associated with the progression of cardiac fibrosis. In this review, we summarized potential miRNAs and miRNAs-related regulatory mechanisms for cardiac fibrosis and discussed the potential clinical application of miRNAs in cardiac fibrosis.https://www.mdpi.com/2073-4425/13/8/1390cardiac fibrosismiRNAscardiac fibrosis-related signaling pathwaysclinical application |
| spellingShingle | Yuanyuan Zhao Dunfeng Du Shanshan Chen Zhishui Chen Jiajia Zhao New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies Genes cardiac fibrosis miRNAs cardiac fibrosis-related signaling pathways clinical application |
| title | New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies |
| title_full | New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies |
| title_fullStr | New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies |
| title_full_unstemmed | New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies |
| title_short | New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies |
| title_sort | new insights into the functions of micrornas in cardiac fibrosis from mechanisms to therapeutic strategies |
| topic | cardiac fibrosis miRNAs cardiac fibrosis-related signaling pathways clinical application |
| url | https://www.mdpi.com/2073-4425/13/8/1390 |
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