Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization.
<h4>Background</h4>In pregnancies obtained by in-vitro fertilization (IVF) the exact day of conception is known. For that reason, IVF pregnancies are currently dated according to the day of oocytes retrieval and consequent embryo transfer. The aim of the present study is to determine whe...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272447 |
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| author | Agnese Maria Chiara Rapisarda Edgardo Somigliana Chiara Dallagiovanna Marco Reschini Maria Grazia Pezone Veronica Accurti Giuditta Ferrara Nicola Persico Simona Boito |
| author_facet | Agnese Maria Chiara Rapisarda Edgardo Somigliana Chiara Dallagiovanna Marco Reschini Maria Grazia Pezone Veronica Accurti Giuditta Ferrara Nicola Persico Simona Boito |
| author_sort | Agnese Maria Chiara Rapisarda |
| collection | DOAJ |
| description | <h4>Background</h4>In pregnancies obtained by in-vitro fertilization (IVF) the exact day of conception is known. For that reason, IVF pregnancies are currently dated according to the day of oocytes retrieval and consequent embryo transfer. The aim of the present study is to determine whether the knowledge of the exact day of conception in IVF pregnancies is a sufficient argument against dating these pregnancies by first trimester ultrasound measurement of the crown-rump length (CRL), as it is recommended in natural conceptions.<h4>Methods</h4>A retrospective study was performed, including all women with singleton pregnancies conceived by IVF who underwent the first-trimester ultrasound scan for the screening of aneuploidies between January 2014 and June 2019. For each pregnancy GA was determined using two alternative methods: one based on the date of embryo transfer (GAIVF), and one based on ultrasound measurement of CRL (GAUS). GA were compared to search for any discrepancy. The impact of pregnancy dating on obstetric outcome was evaluated.<h4>Results</h4>Overall, 249 women were included. Comparing GAUS and GAIVF, a median difference of 1 [0 - 2] days emerged (p<0.001), with GAUS being in advance compared to GAIVF. This discrepancy persisted when subgroups were analyzed comparing different IVF procedures (conventional IVF versus ICSI, cleavage versus blastocyst transfer, frozen versus fresh transfer). No impact of the dating method on obstetric outcomes was observed, being no differences in the rate of preterm birth or abnormal fetal growth.<h4>Conclusions</h4>In IVF pregnancies GAUS and GAIVF are not overlapping, since GAUS is mildly greater than GAIVF. This could be due to an anticipated ovulation and fertilization in IVF pregnancy, rather than an accelerated embryo development. For that reason, it would be appropriate to date IVF pregnancies according to GAUS, despite a known date of conception, to re-align IVF pregnancies to natural ones. |
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| id | doaj.art-df60c46e490949dcbc260a45f1d39b1c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T07:30:43Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-df60c46e490949dcbc260a45f1d39b1c2022-12-22T02:56:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027244710.1371/journal.pone.0272447Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization.Agnese Maria Chiara RapisardaEdgardo SomiglianaChiara DallagiovannaMarco ReschiniMaria Grazia PezoneVeronica AccurtiGiuditta FerraraNicola PersicoSimona Boito<h4>Background</h4>In pregnancies obtained by in-vitro fertilization (IVF) the exact day of conception is known. For that reason, IVF pregnancies are currently dated according to the day of oocytes retrieval and consequent embryo transfer. The aim of the present study is to determine whether the knowledge of the exact day of conception in IVF pregnancies is a sufficient argument against dating these pregnancies by first trimester ultrasound measurement of the crown-rump length (CRL), as it is recommended in natural conceptions.<h4>Methods</h4>A retrospective study was performed, including all women with singleton pregnancies conceived by IVF who underwent the first-trimester ultrasound scan for the screening of aneuploidies between January 2014 and June 2019. For each pregnancy GA was determined using two alternative methods: one based on the date of embryo transfer (GAIVF), and one based on ultrasound measurement of CRL (GAUS). GA were compared to search for any discrepancy. The impact of pregnancy dating on obstetric outcome was evaluated.<h4>Results</h4>Overall, 249 women were included. Comparing GAUS and GAIVF, a median difference of 1 [0 - 2] days emerged (p<0.001), with GAUS being in advance compared to GAIVF. This discrepancy persisted when subgroups were analyzed comparing different IVF procedures (conventional IVF versus ICSI, cleavage versus blastocyst transfer, frozen versus fresh transfer). No impact of the dating method on obstetric outcomes was observed, being no differences in the rate of preterm birth or abnormal fetal growth.<h4>Conclusions</h4>In IVF pregnancies GAUS and GAIVF are not overlapping, since GAUS is mildly greater than GAIVF. This could be due to an anticipated ovulation and fertilization in IVF pregnancy, rather than an accelerated embryo development. For that reason, it would be appropriate to date IVF pregnancies according to GAUS, despite a known date of conception, to re-align IVF pregnancies to natural ones.https://doi.org/10.1371/journal.pone.0272447 |
| spellingShingle | Agnese Maria Chiara Rapisarda Edgardo Somigliana Chiara Dallagiovanna Marco Reschini Maria Grazia Pezone Veronica Accurti Giuditta Ferrara Nicola Persico Simona Boito Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. PLoS ONE |
| title | Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. |
| title_full | Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. |
| title_fullStr | Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. |
| title_full_unstemmed | Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. |
| title_short | Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization. |
| title_sort | clinical implications of first trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization |
| url | https://doi.org/10.1371/journal.pone.0272447 |
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