Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have revealed a strong association between mutations in genes encoding many RNA-binding proteins (RBPs), including TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, TIA-1, and EWSR1, and disease onset/progression. RBPs are a g...

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Bibliographic Details
Main Authors: Yuan Chao Xue, Chen Seng Ng, Pinhao Xiang, Huitao Liu, Kevin Zhang, Yasir Mohamud, Honglin Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
aggregation
gene mutations
nucleocytoplasmic transport
RNA-binding proteins
RNA metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00078/full

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