Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report
Abstract Background Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. Case presentation We report a case of...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-02-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-024-01847-4 |
| _version_ | 1797273496151130112 |
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| author | Keigo Nakashima Masakazu Hashimoto Yoshihito Kitamura Makoto Shinohara Mizuki Yamaguchi Michinori Hamaoka Masashi Miguchi Toshihiro Misumi Nobuaki Fujikuni Satoshi Ikeda Yasuhiro Matsugu Takashi Nishisaka Hideki Nakahara |
| author_facet | Keigo Nakashima Masakazu Hashimoto Yoshihito Kitamura Makoto Shinohara Mizuki Yamaguchi Michinori Hamaoka Masashi Miguchi Toshihiro Misumi Nobuaki Fujikuni Satoshi Ikeda Yasuhiro Matsugu Takashi Nishisaka Hideki Nakahara |
| author_sort | Keigo Nakashima |
| collection | DOAJ |
| description | Abstract Background Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. Case presentation We report a case of goblet cell adenocarcinoma with peritoneal metastases. A 62-year-old man underwent appendectomy for acute appendicitis. Intraoperatively, inflammatory white pus and a small amount of dirty ascites were observed in the lower abdomen with severely inflamed appendix. Histopathological examination of the specimen collected during appendectomy revealed goblet cell adenocarcinoma with a positive surgical margin. One month later, additional ileal resection was planned. Laparoscopic examination revealed disseminated nodules throughout the abdominal cavity. Therefore, the patient underwent resection of the peritoneal nodules. The peritoneal specimens confirmed the histopathological findings. Thus we diagnosed the patient with peritoneal dissemination of appendiceal goblet cell adenocarcinoma. Conclusions In cases wherein white pus is observed during surgery for acute appendicitis, considering the possibility of dissemination, collecting samples for histopathological examination, and initiating early treatment are crucial. |
| first_indexed | 2024-03-07T14:44:08Z |
| format | Article |
| id | doaj.art-df6420cedc594a0fb069c859af162bdb |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-03-07T14:44:08Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-df6420cedc594a0fb069c859af162bdb2024-03-05T20:05:53ZengSpringerOpenSurgical Case Reports2198-77932024-02-011011510.1186/s40792-024-01847-4Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case reportKeigo Nakashima0Masakazu Hashimoto1Yoshihito Kitamura2Makoto Shinohara3Mizuki Yamaguchi4Michinori Hamaoka5Masashi Miguchi6Toshihiro Misumi7Nobuaki Fujikuni8Satoshi Ikeda9Yasuhiro Matsugu10Takashi Nishisaka11Hideki Nakahara12Department of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalDepartment of Pathology and Laboratory Medicine, Hiroshima Prefectural HospitalDepartment of Gastroenterological Surgery, Hiroshima Prefectural HospitalAbstract Background Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. Case presentation We report a case of goblet cell adenocarcinoma with peritoneal metastases. A 62-year-old man underwent appendectomy for acute appendicitis. Intraoperatively, inflammatory white pus and a small amount of dirty ascites were observed in the lower abdomen with severely inflamed appendix. Histopathological examination of the specimen collected during appendectomy revealed goblet cell adenocarcinoma with a positive surgical margin. One month later, additional ileal resection was planned. Laparoscopic examination revealed disseminated nodules throughout the abdominal cavity. Therefore, the patient underwent resection of the peritoneal nodules. The peritoneal specimens confirmed the histopathological findings. Thus we diagnosed the patient with peritoneal dissemination of appendiceal goblet cell adenocarcinoma. Conclusions In cases wherein white pus is observed during surgery for acute appendicitis, considering the possibility of dissemination, collecting samples for histopathological examination, and initiating early treatment are crucial.https://doi.org/10.1186/s40792-024-01847-4Appendiceal tumorGoblet cell adenocarcinomaPeritoneal dissemination |
| spellingShingle | Keigo Nakashima Masakazu Hashimoto Yoshihito Kitamura Makoto Shinohara Mizuki Yamaguchi Michinori Hamaoka Masashi Miguchi Toshihiro Misumi Nobuaki Fujikuni Satoshi Ikeda Yasuhiro Matsugu Takashi Nishisaka Hideki Nakahara Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report Surgical Case Reports Appendiceal tumor Goblet cell adenocarcinoma Peritoneal dissemination |
| title | Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report |
| title_full | Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report |
| title_fullStr | Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report |
| title_full_unstemmed | Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report |
| title_short | Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report |
| title_sort | peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis an instructive case report |
| topic | Appendiceal tumor Goblet cell adenocarcinoma Peritoneal dissemination |
| url | https://doi.org/10.1186/s40792-024-01847-4 |
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