Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age
PurposeTo evaluate the clinical characteristics of vitamin D deficiency and its association with iron deficiency anemia (IDA).MethodsA total of 171 children aged less than two years underwent 25-hydroxyvitamin D3 tests between January 2007 and July 2009. The study was classified into two groups: nor...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2011-07-01
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| Series: | Korean Journal of Pediatrics |
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| Online Access: | http://kjp.or.kr/upload/pdf/kjped-54-298.pdf |
| _version_ | 1830374773852471296 |
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| author | Ji Hyun Yoon Cheong Soo Park Ji Young Seo Yun Sun Choi Young Min Ahn |
| author_facet | Ji Hyun Yoon Cheong Soo Park Ji Young Seo Yun Sun Choi Young Min Ahn |
| author_sort | Ji Hyun Yoon |
| collection | DOAJ |
| description | PurposeTo evaluate the clinical characteristics of vitamin D deficiency and its association with iron deficiency anemia (IDA).MethodsA total of 171 children aged less than two years underwent 25-hydroxyvitamin D3 tests between January 2007 and July 2009. The study was classified into two groups: normal and vitamin D insufficiency, by their vitamin 25-hydroxyvitamin D3 levels.ResultsIn total, 120 children were in the normal group (mean age, body weight and heights 12.5±7.0, 9.3±0.9 kg and 76.8±1.1 cm), and 51 children in the vitamin D insufficiency group (9.9±5.4 months, 9.0±0.9 kg and 75.1±0.9 cm). Vitamin D insufficiency was most commonly diagnosed in the spring (44%). The proportion of complete breast-feeding was higher in the insufficiency (92%), and 25.5% of the children in the deficient group also experienced IDA compared that 12% of normal group. Ten children in the insufficiency group experienced bony changes. Six children received calcitriol medication in the normal group, in whom the mean vitamin 25-hydroxyvitamin D3 level increased from 39.6±14.6 ng/mL (pre-medication) to 41.8±17.2 ng/mL (post-medication), and 13 in the insufficiency group, in whom the mean vitamin 25-hydroxyvitamin D3 increased from 20.7±7.0 ng/mL to a mean post-treatment level of 43.7±23.8 ng/mL.ConclusionThis study demonstrated that approximately 30% of children aged ≤2 years experienced vitamin D insufficiency associated with subclinical rickets. Many children also experienced concurrent IDA. Guidelines for vitamin D supplement in such children must therefore be established. |
| first_indexed | 2024-12-20T07:42:59Z |
| format | Article |
| id | doaj.art-df6708e8ae364ac1bb7cd13f274c0b26 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-20T07:42:59Z |
| publishDate | 2011-07-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-df6708e8ae364ac1bb7cd13f274c0b262022-12-21T19:48:05ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582011-07-0154729830310.3345/kjp.2011.54.7.2982011540705Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of ageJi Hyun Yoon0Cheong Soo Park1Ji Young Seo2Yun Sun Choi3Young Min Ahn4Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.Department of Radiology, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.PurposeTo evaluate the clinical characteristics of vitamin D deficiency and its association with iron deficiency anemia (IDA).MethodsA total of 171 children aged less than two years underwent 25-hydroxyvitamin D3 tests between January 2007 and July 2009. The study was classified into two groups: normal and vitamin D insufficiency, by their vitamin 25-hydroxyvitamin D3 levels.ResultsIn total, 120 children were in the normal group (mean age, body weight and heights 12.5±7.0, 9.3±0.9 kg and 76.8±1.1 cm), and 51 children in the vitamin D insufficiency group (9.9±5.4 months, 9.0±0.9 kg and 75.1±0.9 cm). Vitamin D insufficiency was most commonly diagnosed in the spring (44%). The proportion of complete breast-feeding was higher in the insufficiency (92%), and 25.5% of the children in the deficient group also experienced IDA compared that 12% of normal group. Ten children in the insufficiency group experienced bony changes. Six children received calcitriol medication in the normal group, in whom the mean vitamin 25-hydroxyvitamin D3 level increased from 39.6±14.6 ng/mL (pre-medication) to 41.8±17.2 ng/mL (post-medication), and 13 in the insufficiency group, in whom the mean vitamin 25-hydroxyvitamin D3 increased from 20.7±7.0 ng/mL to a mean post-treatment level of 43.7±23.8 ng/mL.ConclusionThis study demonstrated that approximately 30% of children aged ≤2 years experienced vitamin D insufficiency associated with subclinical rickets. Many children also experienced concurrent IDA. Guidelines for vitamin D supplement in such children must therefore be established.http://kjp.or.kr/upload/pdf/kjped-54-298.pdfVitamin D deficiencyinsufficiencyChildRicketsAnemiaIron |
| spellingShingle | Ji Hyun Yoon Cheong Soo Park Ji Young Seo Yun Sun Choi Young Min Ahn Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age Korean Journal of Pediatrics Vitamin D deficiency insufficiency Child Rickets Anemia Iron |
| title | Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age |
| title_full | Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age |
| title_fullStr | Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age |
| title_full_unstemmed | Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age |
| title_short | Clinical characteristics and prevalence of vitamin D insufficiency in children less than two years of age |
| title_sort | clinical characteristics and prevalence of vitamin d insufficiency in children less than two years of age |
| topic | Vitamin D deficiency insufficiency Child Rickets Anemia Iron |
| url | http://kjp.or.kr/upload/pdf/kjped-54-298.pdf |
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