Development of a Chiral Capillary Electrophoresis Method for the Enantioseparation of Verapamil Using Cyclodextrins as Chiral Selectors and Experimental Design Optimization

Development of a Chiral Capillary Electrophoresis Method for the Enantioseparation of Verapamil Using Cyclodextrins as Chiral Selectors and Experimental Design Optimization

Chirality is a property of asymmetry which determines the pharmacokinetic and pharmacological profiles of optically active pharmaceuticals. Verapamil (VER), a calcium channel blocker phenylalkylamine derivative used in the treatment of cardio-vascular diseases, is a chiral compound, marketed as a ra...

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Bibliographic Details
Main Authors:	Melania Cârcu-Dobrin, Gabriel Hancu, Lajos Attila Papp, Ibolya Fülöp, Hajnal Kelemen
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Symmetry
Subjects:	verapamil chiral separation capillary electrophoresis cyclodextrin experimental design molecular modelling
Online Access:	https://www.mdpi.com/2073-8994/13/11/2186

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