LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema
Lymphedema is the accumulation of protein-rich fluid in the interstitium (i.e., dermal backflow (DBF)). Preoperative imaging of the lymphatic vessels is a prerequisite for lymphovenous bypass surgical planning. We investigated the visualization of lymphatic vessels and veins using light-emitting dio...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597922001112 |
| _version_ | 1811166151609155584 |
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| author | Saskia Van Heumen Jonas J.M. Riksen Mithun Kuniyil Ajith Singh Gijs Van Soest Dalibor Vasilic |
| author_facet | Saskia Van Heumen Jonas J.M. Riksen Mithun Kuniyil Ajith Singh Gijs Van Soest Dalibor Vasilic |
| author_sort | Saskia Van Heumen |
| collection | DOAJ |
| description | Lymphedema is the accumulation of protein-rich fluid in the interstitium (i.e., dermal backflow (DBF)). Preoperative imaging of the lymphatic vessels is a prerequisite for lymphovenous bypass surgical planning. We investigated the visualization of lymphatic vessels and veins using light-emitting diode (LED)-based photoacoustic imaging (PAI).Indocyanine-green mediated near-infrared fluorescence lymphography (NIRF-L) was done in fifteen patients with secondary limb lymphedema. Photoacoustic images were acquired in locations where lymphatic vessels and DBF were observed with NIRF-L.We demonstrated that LED-based PAI can visualize and differentiate lymphatic vessels and veins even in the presence of DBF. We observed lymphatic and blood vessels up to depths of 8.3 and 8.6 mm, respectively.Superficial lymphatic vessels and veins can be visualized using LED-based PAI even in the presence of DBF showing the potential for pre-operative assessment. Further development of the technique is needed to improve its usability in clinical settings. |
| first_indexed | 2024-04-10T15:49:02Z |
| format | Article |
| id | doaj.art-df6af10828154e8d80d5903d7a20aa14 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-04-10T15:49:02Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-df6af10828154e8d80d5903d7a20aa142023-02-12T04:14:46ZengElsevierPhotoacoustics2213-59792023-02-0129100446LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedemaSaskia Van Heumen0Jonas J.M. Riksen1Mithun Kuniyil Ajith Singh2Gijs Van Soest3Dalibor Vasilic4Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Cardiology, Erasmus MC, University Medical Center, Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus MC, University Medical Center, Rotterdam, the NetherlandsResearch and Business Development Division, Cyberdyne Inc., Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus MC, University Medical Center, Rotterdam, the NetherlandsDepartment of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Correspondence to: Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.Lymphedema is the accumulation of protein-rich fluid in the interstitium (i.e., dermal backflow (DBF)). Preoperative imaging of the lymphatic vessels is a prerequisite for lymphovenous bypass surgical planning. We investigated the visualization of lymphatic vessels and veins using light-emitting diode (LED)-based photoacoustic imaging (PAI).Indocyanine-green mediated near-infrared fluorescence lymphography (NIRF-L) was done in fifteen patients with secondary limb lymphedema. Photoacoustic images were acquired in locations where lymphatic vessels and DBF were observed with NIRF-L.We demonstrated that LED-based PAI can visualize and differentiate lymphatic vessels and veins even in the presence of DBF. We observed lymphatic and blood vessels up to depths of 8.3 and 8.6 mm, respectively.Superficial lymphatic vessels and veins can be visualized using LED-based PAI even in the presence of DBF showing the potential for pre-operative assessment. Further development of the technique is needed to improve its usability in clinical settings.http://www.sciencedirect.com/science/article/pii/S2213597922001112LymphedemaPhotoacoustic TechniquesExtremitiesMicrosurgeryLymphovenous AnastomosisLymphography |
| spellingShingle | Saskia Van Heumen Jonas J.M. Riksen Mithun Kuniyil Ajith Singh Gijs Van Soest Dalibor Vasilic LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema Photoacoustics Lymphedema Photoacoustic Techniques Extremities Microsurgery Lymphovenous Anastomosis Lymphography |
| title | LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| title_full | LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| title_fullStr | LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| title_full_unstemmed | LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| title_short | LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| title_sort | led based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema |
| topic | Lymphedema Photoacoustic Techniques Extremities Microsurgery Lymphovenous Anastomosis Lymphography |
| url | http://www.sciencedirect.com/science/article/pii/S2213597922001112 |
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