Innovative Strategies for Hair Regrowth and Skin Visualization
Today, about 50% of men and 15–30% of women are estimated to face hair-related problems, which create a significant psychological burden. Conventional treatments, including drug therapy and transplantation, remain the main strategies for the clinical management of these problems. However, these trea...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/4/1201 |
| _version_ | 1827744000004587520 |
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| author | Qiuying Mai Yanhua Han Guopan Cheng Rui Ma Zhao Yan Xiaojia Chen Guangtao Yu Tongkai Chen Shu Zhang |
| author_facet | Qiuying Mai Yanhua Han Guopan Cheng Rui Ma Zhao Yan Xiaojia Chen Guangtao Yu Tongkai Chen Shu Zhang |
| author_sort | Qiuying Mai |
| collection | DOAJ |
| description | Today, about 50% of men and 15–30% of women are estimated to face hair-related problems, which create a significant psychological burden. Conventional treatments, including drug therapy and transplantation, remain the main strategies for the clinical management of these problems. However, these treatments are hindered by challenges such as drug-induced adverse effects and poor drug penetration due to the skin’s barrier. Therefore, various efforts have been undertaken to enhance drug permeation based on the mechanisms of hair regrowth. Notably, understanding the delivery and diffusion of topically administered drugs is essential in hair loss research. This review focuses on the advancement of transdermal strategies for hair regrowth, particularly those involving external stimulation and regeneration (topical administration) as well as microneedles (transdermal delivery). Furthermore, it also describes the natural products that have become alternative agents to prevent hair loss. In addition, given that skin visualization is necessary for hair regrowth as it provides information on drug localization within the skin’s structure, this review also discusses skin visualization strategies. Finally, it details the relevant patents and clinical trials in these areas. Together, this review highlights the innovative strategies for skin visualization and hair regrowth, aiming to provide novel ideas to researchers studying hair regrowth in the future. |
| first_indexed | 2024-03-11T04:38:42Z |
| format | Article |
| id | doaj.art-df6b95add31e4ff38f50faac9d5a19c6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:38:42Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-df6b95add31e4ff38f50faac9d5a19c62023-11-17T20:54:09ZengMDPI AGPharmaceutics1999-49232023-04-01154120110.3390/pharmaceutics15041201Innovative Strategies for Hair Regrowth and Skin VisualizationQiuying Mai0Yanhua Han1Guopan Cheng2Rui Ma3Zhao Yan4Xiaojia Chen5Guangtao Yu6Tongkai Chen7Shu Zhang8Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, ChinaStomatological Hospital, Southern Medical University, Guangzhou 510280, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaToday, about 50% of men and 15–30% of women are estimated to face hair-related problems, which create a significant psychological burden. Conventional treatments, including drug therapy and transplantation, remain the main strategies for the clinical management of these problems. However, these treatments are hindered by challenges such as drug-induced adverse effects and poor drug penetration due to the skin’s barrier. Therefore, various efforts have been undertaken to enhance drug permeation based on the mechanisms of hair regrowth. Notably, understanding the delivery and diffusion of topically administered drugs is essential in hair loss research. This review focuses on the advancement of transdermal strategies for hair regrowth, particularly those involving external stimulation and regeneration (topical administration) as well as microneedles (transdermal delivery). Furthermore, it also describes the natural products that have become alternative agents to prevent hair loss. In addition, given that skin visualization is necessary for hair regrowth as it provides information on drug localization within the skin’s structure, this review also discusses skin visualization strategies. Finally, it details the relevant patents and clinical trials in these areas. Together, this review highlights the innovative strategies for skin visualization and hair regrowth, aiming to provide novel ideas to researchers studying hair regrowth in the future.https://www.mdpi.com/1999-4923/15/4/1201hair regrowthskin visualizationmicroneedlesregenerative medicinenatural products |
| spellingShingle | Qiuying Mai Yanhua Han Guopan Cheng Rui Ma Zhao Yan Xiaojia Chen Guangtao Yu Tongkai Chen Shu Zhang Innovative Strategies for Hair Regrowth and Skin Visualization Pharmaceutics hair regrowth skin visualization microneedles regenerative medicine natural products |
| title | Innovative Strategies for Hair Regrowth and Skin Visualization |
| title_full | Innovative Strategies for Hair Regrowth and Skin Visualization |
| title_fullStr | Innovative Strategies for Hair Regrowth and Skin Visualization |
| title_full_unstemmed | Innovative Strategies for Hair Regrowth and Skin Visualization |
| title_short | Innovative Strategies for Hair Regrowth and Skin Visualization |
| title_sort | innovative strategies for hair regrowth and skin visualization |
| topic | hair regrowth skin visualization microneedles regenerative medicine natural products |
| url | https://www.mdpi.com/1999-4923/15/4/1201 |
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