Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows
Abstract Background Up to now, information on the levels of maternally-derived antibodies (MDA) against PCV-2 in suckling piglets born to sows vaccinated with different strategies is scarce in the literature. In the present observational study, the PCV-2-specific MDA titres from piglets from 109 far...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Porcine Health Management |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40813-022-00284-9 |
| _version_ | 1797996108725616640 |
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| author | M. Sibila A. Llorens E. Huerta C. Fablet M. Faderl L. Ferrari N. Rose A. Palzer P. Martelli M. C. Venegas-Vargas D. Fredrickson L. Taylor M. Balasch M. Bandrick J. Segalés |
| author_facet | M. Sibila A. Llorens E. Huerta C. Fablet M. Faderl L. Ferrari N. Rose A. Palzer P. Martelli M. C. Venegas-Vargas D. Fredrickson L. Taylor M. Balasch M. Bandrick J. Segalés |
| author_sort | M. Sibila |
| collection | DOAJ |
| description | Abstract Background Up to now, information on the levels of maternally-derived antibodies (MDA) against PCV-2 in suckling piglets born to sows vaccinated with different strategies is scarce in the literature. In the present observational study, the PCV-2-specific MDA titres from piglets from 109 farms (thirty 3-day-old and thirty 21-day-old piglets per farm) across four different European countries (France n = 30, Germany n = 27, Italy n = 22 and Spain n = 30) using different sow vaccination strategies (during gestation, as a gilt, as a piglet or never) were assessed. Results In all four countries, mean log PCV-2 MDA titres were higher in 3-day-old piglets than in the 3-week-old ones, being significant in most of all the comparisons performed. Within each country, the highest PCV-2-specific MDA titres were observed in the 3-day-old piglets born to sows vaccinated during gestation. Indeed, in the four countries, more than 60% of this subpopulation (3-day-old piglets from sows vaccinated during pregnancy) had the highest log PCV-2 titres detectable with the ELISA technique used in this study. The lowest MDA titres were more variable. Whereas in France and Germany the lowest titres corresponded to 21-day-old piglets born from sows vaccinated as a piglet, in Italy, they corresponded to 21-day-old piglets derived from sows vaccinated as a gilt and in Spain to 21-day-old piglets born from non-vaccinated sows. In this study, PCV-2-specific MDA titres at 3 and 21 days of age were not affected by sow parity. Conclusions Data obtained could be considered as a European global overview of PCV-2-specific MDA titres present in the pre-vaccinated piglet populations in different European countries, with titres tending to be higher in younger piglets, but with values variable among countries and sow vaccination strategies. |
| first_indexed | 2024-04-11T10:12:16Z |
| format | Article |
| id | doaj.art-df71b737de024aeabcf6b86675e2fbce |
| institution | Directory Open Access Journal |
| issn | 2055-5660 |
| language | English |
| last_indexed | 2024-04-11T10:12:16Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Porcine Health Management |
| spelling | doaj.art-df71b737de024aeabcf6b86675e2fbce2022-12-22T04:30:04ZengBMCPorcine Health Management2055-56602022-10-01811810.1186/s40813-022-00284-9Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sowsM. Sibila0A. Llorens1E. Huerta2C. Fablet3M. Faderl4L. Ferrari5N. Rose6A. Palzer7P. Martelli8M. C. Venegas-Vargas9D. Fredrickson10L. Taylor11M. Balasch12M. Bandrick13J. Segalés14Unitat Mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB)Unitat Mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB)Unitat Mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB)ANSES, Laboratoire de Ploufragan-Plouzané-NiortVeterinary Pig Practice ScheideggDepartment of Veterinary Science, University of ParmaANSES, Laboratoire de Ploufragan-Plouzané-NiortVeterinary Pig Practice ScheideggDepartment of Veterinary Science, University of ParmaZoetis Inc.Zoetis Inc.Zoetis Inc.Zoetis Manufacturing and Research Spain S.L. CtraZoetis Inc.Unitat Mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB)Abstract Background Up to now, information on the levels of maternally-derived antibodies (MDA) against PCV-2 in suckling piglets born to sows vaccinated with different strategies is scarce in the literature. In the present observational study, the PCV-2-specific MDA titres from piglets from 109 farms (thirty 3-day-old and thirty 21-day-old piglets per farm) across four different European countries (France n = 30, Germany n = 27, Italy n = 22 and Spain n = 30) using different sow vaccination strategies (during gestation, as a gilt, as a piglet or never) were assessed. Results In all four countries, mean log PCV-2 MDA titres were higher in 3-day-old piglets than in the 3-week-old ones, being significant in most of all the comparisons performed. Within each country, the highest PCV-2-specific MDA titres were observed in the 3-day-old piglets born to sows vaccinated during gestation. Indeed, in the four countries, more than 60% of this subpopulation (3-day-old piglets from sows vaccinated during pregnancy) had the highest log PCV-2 titres detectable with the ELISA technique used in this study. The lowest MDA titres were more variable. Whereas in France and Germany the lowest titres corresponded to 21-day-old piglets born from sows vaccinated as a piglet, in Italy, they corresponded to 21-day-old piglets derived from sows vaccinated as a gilt and in Spain to 21-day-old piglets born from non-vaccinated sows. In this study, PCV-2-specific MDA titres at 3 and 21 days of age were not affected by sow parity. Conclusions Data obtained could be considered as a European global overview of PCV-2-specific MDA titres present in the pre-vaccinated piglet populations in different European countries, with titres tending to be higher in younger piglets, but with values variable among countries and sow vaccination strategies.https://doi.org/10.1186/s40813-022-00284-9Porcine circovirus 2Maternally-derived antibodiesSow vaccination |
| spellingShingle | M. Sibila A. Llorens E. Huerta C. Fablet M. Faderl L. Ferrari N. Rose A. Palzer P. Martelli M. C. Venegas-Vargas D. Fredrickson L. Taylor M. Balasch M. Bandrick J. Segalés Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows Porcine Health Management Porcine circovirus 2 Maternally-derived antibodies Sow vaccination |
| title | Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows |
| title_full | Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows |
| title_fullStr | Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows |
| title_full_unstemmed | Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows |
| title_short | Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3- and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows |
| title_sort | descriptive analyses of maternally derived antibody levels against porcine circovirus 2 pcv 2 in 3 and 21 day old piglets from farms of four european countries using different vaccination protocols in sows |
| topic | Porcine circovirus 2 Maternally-derived antibodies Sow vaccination |
| url | https://doi.org/10.1186/s40813-022-00284-9 |
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