Heart Alterations after Domoic Acid Administration in Rats
Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. In the present study we have addressed the l...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-03-01
|
| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/8/3/68 |
| _version_ | 1828146095082962944 |
|---|---|
| author | Andres C. Vieira José Manuel Cifuentes Roberto Bermúdez Sara F. Ferreiro Albina Román Castro Luis M. Botana |
| author_facet | Andres C. Vieira José Manuel Cifuentes Roberto Bermúdez Sara F. Ferreiro Albina Román Castro Luis M. Botana |
| author_sort | Andres C. Vieira |
| collection | DOAJ |
| description | Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. In the present study we have addressed the long-term toxicological effects (30 days) of DA intraperitoneal administration in rats. Different histological techniques were employed in order to study DA toxicity in heart, an organ which has not been thoroughly studied after DA intoxication to date. The presence of DA was detected by immunohistochemical assays, and cellular alterations were observed both by optical and transmission electron microscopy. Although histological staining methods did not provide any observable tissue damage, transmission electron microscopy showed several injuries: a moderate lysis of myofibrils and loss of mitochondrial conformation. This is the first time the association between heart damage and the presence of the toxin has been observed. |
| first_indexed | 2024-04-11T20:42:06Z |
| format | Article |
| id | doaj.art-df72c77e210a4e6391dc1360dc92bdc5 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T20:42:06Z |
| publishDate | 2016-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-df72c77e210a4e6391dc1360dc92bdc52022-12-22T04:04:11ZengMDPI AGToxins2072-66512016-03-01836810.3390/toxins8030068toxins8030068Heart Alterations after Domoic Acid Administration in RatsAndres C. Vieira0José Manuel Cifuentes1Roberto Bermúdez2Sara F. Ferreiro3Albina Román Castro4Luis M. Botana5Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, SpainDepartamento de Anatomía, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, SpainDepartamento de Anatomía, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, SpainDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, SpainRede de Infraestruturas de Apoio á Investigación e ao Desenvolvemento Tecnolóxico (RIADT) Lugo, Universidad de Santiago de Compostela, Lugo 27002, SpainDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, SpainDomoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. In the present study we have addressed the long-term toxicological effects (30 days) of DA intraperitoneal administration in rats. Different histological techniques were employed in order to study DA toxicity in heart, an organ which has not been thoroughly studied after DA intoxication to date. The presence of DA was detected by immunohistochemical assays, and cellular alterations were observed both by optical and transmission electron microscopy. Although histological staining methods did not provide any observable tissue damage, transmission electron microscopy showed several injuries: a moderate lysis of myofibrils and loss of mitochondrial conformation. This is the first time the association between heart damage and the presence of the toxin has been observed.http://www.mdpi.com/2072-6651/8/3/68cardiotoxicitydomoic acidelectron microscopyimmunohistochemistryphycotoxin |
| spellingShingle | Andres C. Vieira José Manuel Cifuentes Roberto Bermúdez Sara F. Ferreiro Albina Román Castro Luis M. Botana Heart Alterations after Domoic Acid Administration in Rats Toxins cardiotoxicity domoic acid electron microscopy immunohistochemistry phycotoxin |
| title | Heart Alterations after Domoic Acid Administration in Rats |
| title_full | Heart Alterations after Domoic Acid Administration in Rats |
| title_fullStr | Heart Alterations after Domoic Acid Administration in Rats |
| title_full_unstemmed | Heart Alterations after Domoic Acid Administration in Rats |
| title_short | Heart Alterations after Domoic Acid Administration in Rats |
| title_sort | heart alterations after domoic acid administration in rats |
| topic | cardiotoxicity domoic acid electron microscopy immunohistochemistry phycotoxin |
| url | http://www.mdpi.com/2072-6651/8/3/68 |
| work_keys_str_mv | AT andrescvieira heartalterationsafterdomoicacidadministrationinrats AT josemanuelcifuentes heartalterationsafterdomoicacidadministrationinrats AT robertobermudez heartalterationsafterdomoicacidadministrationinrats AT sarafferreiro heartalterationsafterdomoicacidadministrationinrats AT albinaromancastro heartalterationsafterdomoicacidadministrationinrats AT luismbotana heartalterationsafterdomoicacidadministrationinrats |