How to study biofilms: technological advancements in clinical biofilm research
Biofilm formation is an important survival strategy commonly used by bacteria and fungi, which are embedded in a protective extracellular matrix of organic polymers. They are ubiquitous in nature, including humans and other animals, and they can be surface- and non-surface-associated, making them ca...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1335389/full |
| _version_ | 1797393031515602944 |
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| author | Leanne Cleaver James A. Garnett |
| author_facet | Leanne Cleaver James A. Garnett |
| author_sort | Leanne Cleaver |
| collection | DOAJ |
| description | Biofilm formation is an important survival strategy commonly used by bacteria and fungi, which are embedded in a protective extracellular matrix of organic polymers. They are ubiquitous in nature, including humans and other animals, and they can be surface- and non-surface-associated, making them capable of growing in and on many different parts of the body. Biofilms are also complex, forming polymicrobial communities that are difficult to eradicate due to their unique growth dynamics, and clinical infections associated with biofilms are a huge burden in the healthcare setting, as they are often difficult to diagnose and to treat. Our understanding of biofilm formation and development is a fast-paced and important research focus. This review aims to describe the advancements in clinical biofilm research, including both in vitro and in vivo biofilm models, imaging techniques and techniques to analyse the biological functions of the biofilm. |
| first_indexed | 2024-03-08T23:56:14Z |
| format | Article |
| id | doaj.art-df73db973d1543568950c6b4bcbf0dba |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T23:56:14Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-df73db973d1543568950c6b4bcbf0dba2023-12-13T04:58:11ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-12-011310.3389/fcimb.2023.13353891335389How to study biofilms: technological advancements in clinical biofilm researchLeanne CleaverJames A. GarnettBiofilm formation is an important survival strategy commonly used by bacteria and fungi, which are embedded in a protective extracellular matrix of organic polymers. They are ubiquitous in nature, including humans and other animals, and they can be surface- and non-surface-associated, making them capable of growing in and on many different parts of the body. Biofilms are also complex, forming polymicrobial communities that are difficult to eradicate due to their unique growth dynamics, and clinical infections associated with biofilms are a huge burden in the healthcare setting, as they are often difficult to diagnose and to treat. Our understanding of biofilm formation and development is a fast-paced and important research focus. This review aims to describe the advancements in clinical biofilm research, including both in vitro and in vivo biofilm models, imaging techniques and techniques to analyse the biological functions of the biofilm.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1335389/fullbiofilmbiofilm modelbiofilm imagingbiofilm analysisinfectionhost-microbe interactions |
| spellingShingle | Leanne Cleaver James A. Garnett How to study biofilms: technological advancements in clinical biofilm research Frontiers in Cellular and Infection Microbiology biofilm biofilm model biofilm imaging biofilm analysis infection host-microbe interactions |
| title | How to study biofilms: technological advancements in clinical biofilm research |
| title_full | How to study biofilms: technological advancements in clinical biofilm research |
| title_fullStr | How to study biofilms: technological advancements in clinical biofilm research |
| title_full_unstemmed | How to study biofilms: technological advancements in clinical biofilm research |
| title_short | How to study biofilms: technological advancements in clinical biofilm research |
| title_sort | how to study biofilms technological advancements in clinical biofilm research |
| topic | biofilm biofilm model biofilm imaging biofilm analysis infection host-microbe interactions |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1335389/full |
| work_keys_str_mv | AT leannecleaver howtostudybiofilmstechnologicaladvancementsinclinicalbiofilmresearch AT jamesagarnett howtostudybiofilmstechnologicaladvancementsinclinicalbiofilmresearch |