High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study
<p>Abstract</p> <p>Background</p> <p>To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged ≥ 20 years.</p> <p>...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-05-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/8/176 |
| _version_ | 1818362174854135808 |
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| author | Saadat Navid Harati Hadi Ghasemi Asghar Bozorgmanesh Mohammad Hadaegh Farzad Azizi Fereidoun |
| author_facet | Saadat Navid Harati Hadi Ghasemi Asghar Bozorgmanesh Mohammad Hadaegh Farzad Azizi Fereidoun |
| author_sort | Saadat Navid |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged ≥ 20 years.</p> <p>Methods</p> <p>The study population included 9,489 participants of the Tehran Lipid and Glucose Study with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. Age-adjusted logistic regression models were used to estimate the numbers needed to screen (NNTS) to find one person with undiagnosed diabetes.</p> <p>Results</p> <p>The prevalence of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Participants with undiagnosed diabetes had higher age, body mass index (BMI), waist circumference, systolic and diastolic blood pressures, triglycerides (all p values <0.001) and lower HDL-cholesterol (only in women, p < 0.01) compared to normoglycemic subjects. Undiagnosed diabetes was associated with family history of diabetes, increased BMI (≥ 25 kg/m<sup>2</sup>), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-cholesterol levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to a NNTS of 1.6 (95% CI: 1.57–1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded a NNTS of 2.2 (95% CI: 2.1–2.4).</p> <p>Conclusion</p> <p>In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One- third of total cases with diabetes were undiagnosed. Screening individuals with BMI ≥ 25 kg/m<sup>2 </sup>(men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient.</p> |
| first_indexed | 2024-12-13T21:28:24Z |
| format | Article |
| id | doaj.art-df755dba14da481bbfda4386a478f186 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-13T21:28:24Z |
| publishDate | 2008-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-df755dba14da481bbfda4386a478f1862022-12-21T23:30:53ZengBMCBMC Public Health1471-24582008-05-018117610.1186/1471-2458-8-176High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose StudySaadat NavidHarati HadiGhasemi AsgharBozorgmanesh MohammadHadaegh FarzadAzizi Fereidoun<p>Abstract</p> <p>Background</p> <p>To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged ≥ 20 years.</p> <p>Methods</p> <p>The study population included 9,489 participants of the Tehran Lipid and Glucose Study with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. Age-adjusted logistic regression models were used to estimate the numbers needed to screen (NNTS) to find one person with undiagnosed diabetes.</p> <p>Results</p> <p>The prevalence of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Participants with undiagnosed diabetes had higher age, body mass index (BMI), waist circumference, systolic and diastolic blood pressures, triglycerides (all p values <0.001) and lower HDL-cholesterol (only in women, p < 0.01) compared to normoglycemic subjects. Undiagnosed diabetes was associated with family history of diabetes, increased BMI (≥ 25 kg/m<sup>2</sup>), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-cholesterol levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to a NNTS of 1.6 (95% CI: 1.57–1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded a NNTS of 2.2 (95% CI: 2.1–2.4).</p> <p>Conclusion</p> <p>In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One- third of total cases with diabetes were undiagnosed. Screening individuals with BMI ≥ 25 kg/m<sup>2 </sup>(men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient.</p>http://www.biomedcentral.com/1471-2458/8/176 |
| spellingShingle | Saadat Navid Harati Hadi Ghasemi Asghar Bozorgmanesh Mohammad Hadaegh Farzad Azizi Fereidoun High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study BMC Public Health |
| title | High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study |
| title_full | High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study |
| title_fullStr | High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study |
| title_full_unstemmed | High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study |
| title_short | High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study |
| title_sort | high prevalence of undiagnosed diabetes and abnormal glucose tolerance in the iranian urban population tehran lipid and glucose study |
| url | http://www.biomedcentral.com/1471-2458/8/176 |
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