Serum biomarkers in patients with hand-arm vibration injury and in controls
Abstract Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud’s phen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52782-1 |
| _version_ | 1797275241469181952 |
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| author | Eva Tekavec Tohr Nilsson Lars B. Dahlin Elizabeth Huynh Anna Axmon Catarina Nordander Jakob Riddar Monica Kåredal |
| author_facet | Eva Tekavec Tohr Nilsson Lars B. Dahlin Elizabeth Huynh Anna Axmon Catarina Nordander Jakob Riddar Monica Kåredal |
| author_sort | Eva Tekavec |
| collection | DOAJ |
| description | Abstract Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud’s phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury. |
| first_indexed | 2024-03-07T15:10:35Z |
| format | Article |
| id | doaj.art-df7700730760493a830acf6a77bdf092 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:10:35Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-df7700730760493a830acf6a77bdf0922024-03-05T18:42:02ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-52782-1Serum biomarkers in patients with hand-arm vibration injury and in controlsEva Tekavec0Tohr Nilsson1Lars B. Dahlin2Elizabeth Huynh3Anna Axmon4Catarina Nordander5Jakob Riddar6Monica Kåredal7Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund UniversitySection of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå UniversityDepartment of Translational Medicine-Hand Surgery, Lund UniversityOccupational and Environmental Medicine, Region SkåneDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund UniversityDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund UniversityDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund UniversityDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund UniversityAbstract Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud’s phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.https://doi.org/10.1038/s41598-024-52782-1 |
| spellingShingle | Eva Tekavec Tohr Nilsson Lars B. Dahlin Elizabeth Huynh Anna Axmon Catarina Nordander Jakob Riddar Monica Kåredal Serum biomarkers in patients with hand-arm vibration injury and in controls Scientific Reports |
| title | Serum biomarkers in patients with hand-arm vibration injury and in controls |
| title_full | Serum biomarkers in patients with hand-arm vibration injury and in controls |
| title_fullStr | Serum biomarkers in patients with hand-arm vibration injury and in controls |
| title_full_unstemmed | Serum biomarkers in patients with hand-arm vibration injury and in controls |
| title_short | Serum biomarkers in patients with hand-arm vibration injury and in controls |
| title_sort | serum biomarkers in patients with hand arm vibration injury and in controls |
| url | https://doi.org/10.1038/s41598-024-52782-1 |
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