Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy
The interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition of T cells to tumor cells. Immune checkpoint inhibitor (ICI) therapy is emerging as a promising therapeutic option for cancer treatment. However, modulat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/8/1107 |
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| author | Juwon Lee Youngjin Han Wenyu Wang HyunA Jo Heeyeon Kim Soochi Kim Kyung-Min Yang Seong-Jin Kim Danny N. Dhanasekaran Yong Sang Song |
| author_facet | Juwon Lee Youngjin Han Wenyu Wang HyunA Jo Heeyeon Kim Soochi Kim Kyung-Min Yang Seong-Jin Kim Danny N. Dhanasekaran Yong Sang Song |
| author_sort | Juwon Lee |
| collection | DOAJ |
| description | The interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition of T cells to tumor cells. Immune checkpoint inhibitor (ICI) therapy is emerging as a promising therapeutic option for cancer treatment. However, modulating the immune system with ICIs still faces obstacles with severe immunogenic side effects and a lack of response against many cancer types. Plant-derived natural compounds offer regulation on various signaling cascades and have been applied for the treatment of multiple diseases, including cancer. Accumulated evidence provides the possibility of efficacy of phytochemicals in combinational with other therapeutic agents of ICIs, effectively modulating immune checkpoint-related signaling molecules. Recently, several phytochemicals have been reported to show the modulatory effects of immune checkpoints in various cancers in in vivo or in vitro models. This review summarizes druggable immune checkpoints and their regulatory factors. In addition, phytochemicals that are capable of suppressing PD-1/PD-L1 binding, the best-studied target of ICI therapy, were comprehensively summarized and classified according to chemical structure subgroups. It may help extend further research on phytochemicals as candidates of combinational adjuvants. Future clinical trials may validate the synergetic effects of preclinically investigated phytochemicals with ICI therapy. |
| first_indexed | 2024-03-10T08:59:50Z |
| format | Article |
| id | doaj.art-df77798592a842bc9ef825cff9ef924e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:59:50Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-df77798592a842bc9ef825cff9ef924e2023-11-22T06:54:55ZengMDPI AGBiomolecules2218-273X2021-07-01118110710.3390/biom11081107Phytochemicals in Cancer Immune Checkpoint Inhibitor TherapyJuwon Lee0Youngjin Han1Wenyu Wang2HyunA Jo3Heeyeon Kim4Soochi Kim5Kyung-Min Yang6Seong-Jin Kim7Danny N. Dhanasekaran8Yong Sang Song9Cancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaCancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaCancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaCancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaCancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaDepartment of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA 94304, USAMedPacto Inc., 92, Myeongdal-ro, Seocho-gu, Seoul 06668, KoreaMedPacto Inc., 92, Myeongdal-ro, Seocho-gu, Seoul 06668, KoreaDepartment of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USACancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, KoreaThe interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition of T cells to tumor cells. Immune checkpoint inhibitor (ICI) therapy is emerging as a promising therapeutic option for cancer treatment. However, modulating the immune system with ICIs still faces obstacles with severe immunogenic side effects and a lack of response against many cancer types. Plant-derived natural compounds offer regulation on various signaling cascades and have been applied for the treatment of multiple diseases, including cancer. Accumulated evidence provides the possibility of efficacy of phytochemicals in combinational with other therapeutic agents of ICIs, effectively modulating immune checkpoint-related signaling molecules. Recently, several phytochemicals have been reported to show the modulatory effects of immune checkpoints in various cancers in in vivo or in vitro models. This review summarizes druggable immune checkpoints and their regulatory factors. In addition, phytochemicals that are capable of suppressing PD-1/PD-L1 binding, the best-studied target of ICI therapy, were comprehensively summarized and classified according to chemical structure subgroups. It may help extend further research on phytochemicals as candidates of combinational adjuvants. Future clinical trials may validate the synergetic effects of preclinically investigated phytochemicals with ICI therapy.https://www.mdpi.com/2218-273X/11/8/1107phytochemicalimmune checkpointPD-1PD-L1cancer immunotherapy |
| spellingShingle | Juwon Lee Youngjin Han Wenyu Wang HyunA Jo Heeyeon Kim Soochi Kim Kyung-Min Yang Seong-Jin Kim Danny N. Dhanasekaran Yong Sang Song Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy Biomolecules phytochemical immune checkpoint PD-1 PD-L1 cancer immunotherapy |
| title | Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy |
| title_full | Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy |
| title_fullStr | Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy |
| title_full_unstemmed | Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy |
| title_short | Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy |
| title_sort | phytochemicals in cancer immune checkpoint inhibitor therapy |
| topic | phytochemical immune checkpoint PD-1 PD-L1 cancer immunotherapy |
| url | https://www.mdpi.com/2218-273X/11/8/1107 |
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