Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion
Abstract Introduction To profile conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after instillation of daily topical cyclosporine-A (CsA) 0.1% cationic emulsion (Ikervis), and to evaluate patients’ tolerance to these eye drops. Methods Nineteen partic...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-03-01
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| Series: | Ophthalmology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40123-023-00686-0 |
| _version_ | 1797832255269240832 |
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| author | Louis Tong Elizabeth Wen Ling Lim Sharon Wan Jie Yeo Aihua Hou Yeh Ching Linn Aloysius Ho Hein Than Jeffrey Kim Siang Quek William Ying Khee Hwang Francesca Lorraine Wei Inng Lim Li Lim |
| author_facet | Louis Tong Elizabeth Wen Ling Lim Sharon Wan Jie Yeo Aihua Hou Yeh Ching Linn Aloysius Ho Hein Than Jeffrey Kim Siang Quek William Ying Khee Hwang Francesca Lorraine Wei Inng Lim Li Lim |
| author_sort | Louis Tong |
| collection | DOAJ |
| description | Abstract Introduction To profile conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after instillation of daily topical cyclosporine-A (CsA) 0.1% cationic emulsion (Ikervis), and to evaluate patients’ tolerance to these eye drops. Methods Nineteen participants were prescribed Ikervis prophylaxis once daily to both eyes from 3–5 weeks pre-HSCT to 12 months post-HSCT. The outcome measure was conjunctival T cell proportions from flow cytometry after impression cytology. Covariates included visual acuity, intraocular pressure, slit lamp and fundal examination, dry eye (SPEED) and quality of life questionnaires, non-invasive keratograph tear break-up time (NIKBUT), conjunctival redness, meibography, lipid thickness, Schirmer test, tear cytokines, fluorescein staining, tear osmolarity, and meibomian gland expressibility. Results The conjunctival T cell analysis showed either stable or decreased proportions of conjunctival CD4 T cells at the last visit from baseline in compliant patients. CD4 proportions were increased in non-compliant patients and in the single patient who developed ocular graft-versus-host disease (GVHD). All patients were tolerant to Ikervis but 6/19 were not compliant. In the majority of patients, vision did not affect activities of daily living. Pre- and post-HSCT up to the last study visit, there was no statistically significant change in clinical covariates. Only one participant developed ocular GVHD at 9 months post-HSCT. Conclusion Superficial conjunctival T cell profile reflects compliance to daily topical Ikervis eye drops and clinical ocular surface parameters in allogenic HSCT patients. Tolerance is comparable to other formulations of topical CsA in the first 12 months. ClinicalTrials.gov Identifier NCT04636918. URL: https://clinicaltrials.gov/ct2/show/NCT04636918?cond=ocular+Graft+Versus+Host+Disease&cntry=SG&draw=2&rank=2 . |
| first_indexed | 2024-04-09T14:04:54Z |
| format | Article |
| id | doaj.art-df77efa742534c4bb88a29e362039a82 |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-04-09T14:04:54Z |
| publishDate | 2023-03-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-df77efa742534c4bb88a29e362039a822023-05-07T11:07:32ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-03-011231547156710.1007/s40123-023-00686-0Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic EmulsionLouis Tong0Elizabeth Wen Ling Lim1Sharon Wan Jie Yeo2Aihua Hou3Yeh Ching Linn4Aloysius Ho5Hein Than6Jeffrey Kim Siang Quek7William Ying Khee Hwang8Francesca Lorraine Wei Inng Lim9Li Lim10Corneal and External Eye Disease Service, Singapore National Eye CentreOcular Surface Research Group, Singapore Eye Research InstituteOcular Surface Research Group, Singapore Eye Research InstituteOcular Surface Research Group, Singapore Eye Research InstituteDepartment of Haematology, Singapore General HospitalDepartment of Haematology, Singapore General HospitalDepartment of Haematology, Singapore General HospitalDepartment of Haematology, Singapore General HospitalDepartment of Haematology, Singapore General HospitalDepartment of Haematology, Singapore General HospitalCorneal and External Eye Disease Service, Singapore National Eye CentreAbstract Introduction To profile conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after instillation of daily topical cyclosporine-A (CsA) 0.1% cationic emulsion (Ikervis), and to evaluate patients’ tolerance to these eye drops. Methods Nineteen participants were prescribed Ikervis prophylaxis once daily to both eyes from 3–5 weeks pre-HSCT to 12 months post-HSCT. The outcome measure was conjunctival T cell proportions from flow cytometry after impression cytology. Covariates included visual acuity, intraocular pressure, slit lamp and fundal examination, dry eye (SPEED) and quality of life questionnaires, non-invasive keratograph tear break-up time (NIKBUT), conjunctival redness, meibography, lipid thickness, Schirmer test, tear cytokines, fluorescein staining, tear osmolarity, and meibomian gland expressibility. Results The conjunctival T cell analysis showed either stable or decreased proportions of conjunctival CD4 T cells at the last visit from baseline in compliant patients. CD4 proportions were increased in non-compliant patients and in the single patient who developed ocular graft-versus-host disease (GVHD). All patients were tolerant to Ikervis but 6/19 were not compliant. In the majority of patients, vision did not affect activities of daily living. Pre- and post-HSCT up to the last study visit, there was no statistically significant change in clinical covariates. Only one participant developed ocular GVHD at 9 months post-HSCT. Conclusion Superficial conjunctival T cell profile reflects compliance to daily topical Ikervis eye drops and clinical ocular surface parameters in allogenic HSCT patients. Tolerance is comparable to other formulations of topical CsA in the first 12 months. ClinicalTrials.gov Identifier NCT04636918. URL: https://clinicaltrials.gov/ct2/show/NCT04636918?cond=ocular+Graft+Versus+Host+Disease&cntry=SG&draw=2&rank=2 .https://doi.org/10.1007/s40123-023-00686-0Conjunctival T cellsDry eye diseaseGraft-versus-host diseaseImmunologyOcular surface diseaseProphylaxis |
| spellingShingle | Louis Tong Elizabeth Wen Ling Lim Sharon Wan Jie Yeo Aihua Hou Yeh Ching Linn Aloysius Ho Hein Than Jeffrey Kim Siang Quek William Ying Khee Hwang Francesca Lorraine Wei Inng Lim Li Lim Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion Ophthalmology and Therapy Conjunctival T cells Dry eye disease Graft-versus-host disease Immunology Ocular surface disease Prophylaxis |
| title | Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion |
| title_full | Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion |
| title_fullStr | Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion |
| title_full_unstemmed | Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion |
| title_short | Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion |
| title_sort | conjunctival t cell profile in allogeneic hematopoietic stem cell transplant patients after instilling topical cyclosporine a 0 1 cationic emulsion |
| topic | Conjunctival T cells Dry eye disease Graft-versus-host disease Immunology Ocular surface disease Prophylaxis |
| url | https://doi.org/10.1007/s40123-023-00686-0 |
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