Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial
Abstract Aim Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in pat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-023-00231-9 |
| _version_ | 1797863231056773120 |
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| author | Pilar Sanchis Paula Calvo Antelm Pujol Rosmeri Rivera Francisco Berga Regina Fortuny Antonia Costa-Bauza Felix Grases Luis Masmiquel |
| author_facet | Pilar Sanchis Paula Calvo Antelm Pujol Rosmeri Rivera Francisco Berga Regina Fortuny Antonia Costa-Bauza Felix Grases Luis Masmiquel |
| author_sort | Pilar Sanchis |
| collection | DOAJ |
| description | Abstract Aim Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2. Methods We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period. Results Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta. Conclusion This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications. |
| first_indexed | 2024-04-09T22:32:14Z |
| format | Article |
| id | doaj.art-df79049ae0584a999679194db6aa2f7b |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-04-09T22:32:14Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-df79049ae0584a999679194db6aa2f7b2023-03-22T12:43:03ZengNature Publishing GroupNutrition & Diabetes2044-40522023-02-011311910.1038/s41387-023-00231-9Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trialPilar Sanchis0Paula Calvo1Antelm Pujol2Rosmeri Rivera3Francisco Berga4Regina Fortuny5Antonia Costa-Bauza6Felix Grases7Luis Masmiquel8Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa]Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa]Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Institute of Health Sciences Research [IdISBa]Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Institute of Health Sciences Research [IdISBa]Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa]Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Institute of Health Sciences Research [IdISBa]Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa]Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa]Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Institute of Health Sciences Research [IdISBa]Abstract Aim Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2. Methods We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period. Results Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta. Conclusion This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.https://doi.org/10.1038/s41387-023-00231-9 |
| spellingShingle | Pilar Sanchis Paula Calvo Antelm Pujol Rosmeri Rivera Francisco Berga Regina Fortuny Antonia Costa-Bauza Felix Grases Luis Masmiquel Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial Nutrition & Diabetes |
| title | Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial |
| title_full | Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial |
| title_fullStr | Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial |
| title_full_unstemmed | Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial |
| title_short | Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial |
| title_sort | daily phytate intake increases adiponectin levels among patients with diabetes type 2 a randomized crossover trial |
| url | https://doi.org/10.1038/s41387-023-00231-9 |
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