Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i>
The importance of RNAs is commonly recognised thanks to protein-coding RNAs, whereas non-coding RNAs (ncRNAs) were conventionally regarded as ‘junk’. In the last decade, ncRNAs’ significance and roles are becoming noticeable in various biological activities, including those in hormonal and metabolic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/152 |
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| author | Ki-Kei Chan Ting-Fung Chan William Bendena Jerome H. L. Hui |
| author_facet | Ki-Kei Chan Ting-Fung Chan William Bendena Jerome H. L. Hui |
| author_sort | Ki-Kei Chan |
| collection | DOAJ |
| description | The importance of RNAs is commonly recognised thanks to protein-coding RNAs, whereas non-coding RNAs (ncRNAs) were conventionally regarded as ‘junk’. In the last decade, ncRNAs’ significance and roles are becoming noticeable in various biological activities, including those in hormonal and metabolic regulation. Among the ncRNAs: microRNA (miRNA) is a small RNA transcript with ~20 nucleotides in length; long non-coding RNA (lncRNA) is an RNA transcript with >200 nucleotides; and circular RNA (circRNA) is derived from back-splicing of pre-mRNA. These ncRNAs can regulate gene expression levels at epigenetic, transcriptional, and post-transcriptional levels through various mechanisms in insects. A better understanding of these crucial regulators is essential to both basic and applied entomology. In this review, we intend to summarise and discuss the current understanding and knowledge of miRNA, lncRNA, and circRNA in the best-studied insect model, the fruit fly <i>Drosophila</i>. |
| first_indexed | 2024-03-11T08:26:42Z |
| format | Article |
| id | doaj.art-df7aad711ccb4f63a90b263a7b79f05d |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:42Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-df7aad711ccb4f63a90b263a7b79f05d2023-11-16T22:03:38ZengMDPI AGMetabolites2218-19892023-01-0113215210.3390/metabo13020152Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i>Ki-Kei Chan0Ting-Fung Chan1William Bendena2Jerome H. L. Hui3State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaState Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Biology, Queen’s University, Kingston, ON K7L 3N6, CanadaState Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaThe importance of RNAs is commonly recognised thanks to protein-coding RNAs, whereas non-coding RNAs (ncRNAs) were conventionally regarded as ‘junk’. In the last decade, ncRNAs’ significance and roles are becoming noticeable in various biological activities, including those in hormonal and metabolic regulation. Among the ncRNAs: microRNA (miRNA) is a small RNA transcript with ~20 nucleotides in length; long non-coding RNA (lncRNA) is an RNA transcript with >200 nucleotides; and circular RNA (circRNA) is derived from back-splicing of pre-mRNA. These ncRNAs can regulate gene expression levels at epigenetic, transcriptional, and post-transcriptional levels through various mechanisms in insects. A better understanding of these crucial regulators is essential to both basic and applied entomology. In this review, we intend to summarise and discuss the current understanding and knowledge of miRNA, lncRNA, and circRNA in the best-studied insect model, the fruit fly <i>Drosophila</i>.https://www.mdpi.com/2218-1989/13/2/152ncRNAmiRNAlncRNAcircRNA<i>Drosophila</i>hormone |
| spellingShingle | Ki-Kei Chan Ting-Fung Chan William Bendena Jerome H. L. Hui Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> Metabolites ncRNA miRNA lncRNA circRNA <i>Drosophila</i> hormone |
| title | Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> |
| title_full | Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> |
| title_fullStr | Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> |
| title_full_unstemmed | Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> |
| title_short | Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly <i>Drosophila</i> |
| title_sort | noncoding rna regulation of hormonal and metabolic systems in the fruit fly i drosophila i |
| topic | ncRNA miRNA lncRNA circRNA <i>Drosophila</i> hormone |
| url | https://www.mdpi.com/2218-1989/13/2/152 |
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