The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis
Background and objective:Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogene...
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| Format: | Article |
| Language: | English |
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Iranian Society of Pathology
2017-12-01
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| Series: | Iranian Journal of Pathology |
| Subjects: | |
| Online Access: | https://ijp.iranpath.org/article_28318_ad2beed2ee5504abb811d60eec159d4f.pdf |
| _version_ | 1819008911291711488 |
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| author | Noushin Jalayer naderi Hasan Semyari Reza Hemmati |
| author_facet | Noushin Jalayer naderi Hasan Semyari Reza Hemmati |
| author_sort | Noushin Jalayer naderi |
| collection | DOAJ |
| description | Background and objective:Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis. Materials& Methods: 52 paraffin embedded block of gingiva tissues with periodontitis obtained from 30 nonsmokers and 22 smokers undergoing flap surgery were examined immunohistochemically for VEGF expression. Mast cell counts was completed on toluidine blue stained slides. Exposure to cigarette smoking was calculated by the number of packs × year. Patients were classified into 4 groups based on the number of smoked cigarettes. The correlation between VEGF expression and mast cell counts was evaluated and compared in nonsmokers and smokers. Results: The mean number of mast cells (p=0.004) and average value of VEGF expression (p = 0.000) in nonsmokers was significantly higher than smokers. No correlation was noted between VEGF expression / mast cell counts and number of smoked cigarettes in four groups of smokers (p=0.29,0.12 , 0.20 and 0.11, respectively). Conclusion: Mast cells and VEGF expression may account for suppressive effect of cigarette smoking on blood vessels in periodontitis. |
| first_indexed | 2024-12-21T00:47:59Z |
| format | Article |
| id | doaj.art-df7c02bebbcf44aeb19ff9e2f9243260 |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-21T00:47:59Z |
| publishDate | 2017-12-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-df7c02bebbcf44aeb19ff9e2f92432602022-12-21T19:21:29ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562017-12-0112438439110.30699/ijp.2017.2831828318The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic PeriodontitisNoushin Jalayer naderi0Hasan Semyari1Reza Hemmati2Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahed UniversityDepartment of Periodontic, Faculty of Dentistry, Shahed UniversityFaculty of Dentistry, Shahed UniversityBackground and objective:Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis. Materials& Methods: 52 paraffin embedded block of gingiva tissues with periodontitis obtained from 30 nonsmokers and 22 smokers undergoing flap surgery were examined immunohistochemically for VEGF expression. Mast cell counts was completed on toluidine blue stained slides. Exposure to cigarette smoking was calculated by the number of packs × year. Patients were classified into 4 groups based on the number of smoked cigarettes. The correlation between VEGF expression and mast cell counts was evaluated and compared in nonsmokers and smokers. Results: The mean number of mast cells (p=0.004) and average value of VEGF expression (p = 0.000) in nonsmokers was significantly higher than smokers. No correlation was noted between VEGF expression / mast cell counts and number of smoked cigarettes in four groups of smokers (p=0.29,0.12 , 0.20 and 0.11, respectively). Conclusion: Mast cells and VEGF expression may account for suppressive effect of cigarette smoking on blood vessels in periodontitis.https://ijp.iranpath.org/article_28318_ad2beed2ee5504abb811d60eec159d4f.pdfangiogenesischronic periodontitismast cell densitycigarette smokingvascular endothelial growth factor (vegf) |
| spellingShingle | Noushin Jalayer naderi Hasan Semyari Reza Hemmati The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis Iranian Journal of Pathology angiogenesis chronic periodontitis mast cell density cigarette smoking vascular endothelial growth factor (vegf) |
| title | The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis |
| title_full | The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis |
| title_fullStr | The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis |
| title_full_unstemmed | The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis |
| title_short | The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis |
| title_sort | effect of smoking on mast cells density and angiogenesis in chronic periodontitis |
| topic | angiogenesis chronic periodontitis mast cell density cigarette smoking vascular endothelial growth factor (vegf) |
| url | https://ijp.iranpath.org/article_28318_ad2beed2ee5504abb811d60eec159d4f.pdf |
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