Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse
<b>Background:</b> The present retrospective observational study aims to identify differences in clinical features and peripheral biomarkers among patients affected by substance-induced psychotic disorder (SIPD) according to the primary substance of abuse. <b>Methods:</b> A s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/3/325 |
| _version_ | 1797240375227711488 |
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| author | Martina Di Paolo Antonia Calabrese Guido Nosari Valentina Ciappolino Luisa Cirella Alice Caldiroli Enrico Capuzzi Massimo Clerici Massimiliano Buoli |
| author_facet | Martina Di Paolo Antonia Calabrese Guido Nosari Valentina Ciappolino Luisa Cirella Alice Caldiroli Enrico Capuzzi Massimo Clerici Massimiliano Buoli |
| author_sort | Martina Di Paolo |
| collection | DOAJ |
| description | <b>Background:</b> The present retrospective observational study aims to identify differences in clinical features and peripheral biomarkers among patients affected by substance-induced psychotic disorder (SIPD) according to the primary substance of abuse. <b>Methods:</b> A sample of 218 patients was divided into three groups according to the type of consumed substance: alcohol, cannabis, and psychostimulants. The three groups were compared using one-way analyses of variance (ANOVAs) for continuous variables and χ<sup>2</sup> tests for qualitative variables. After excluding the alcohol-induced psychotic disorder group, the same analyses were repeated. The statistically significant variables from these subsequent analyses were included in a binary logistic regression model to confirm their reliability as predictors of cannabis- or psychostimulant-induced psychotic disorder. <b>Results:</b> Psychotic cannabis abusers were younger (<i>p</i> < 0.01), with illness onset at an earlier age (<i>p</i> < 0.01). Alcohol consumers presented a longer duration of illness (<i>p</i> < 0.01), more frequent previous hospitalizations (<i>p</i> = 0.04) and medical comorbidities (<i>p</i> < 0.01), and higher mean Modified Sad Persons Scale scores (<i>p</i> < 0.01). Finally, psychostimulant abusers had a higher frequency of lifetime history of poly-substance use disorders (<i>p</i> < 0.01). A binary logistic regression analysis revealed that higher mean Brief Psychiatric Rating Scale scores (<i>p</i> < 0.01) and higher sodium (<i>p</i> = 0.012) and hemoglobin (<i>p</i> = 0.040) plasma levels were predictors of cannabis misuse in SIPD patients. <b>Conclusions:</b> Different clinical factors and biochemical parameters con be associated with SIPD according to the main substance of abuse, thus requiring specific management by clinicians. |
| first_indexed | 2024-04-24T18:06:26Z |
| format | Article |
| id | doaj.art-df7df3f47267416180d9b151bc0e831f |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-04-24T18:06:26Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-df7df3f47267416180d9b151bc0e831f2024-03-27T13:50:16ZengMDPI AGJournal of Personalized Medicine2075-44262024-03-0114332510.3390/jpm14030325Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant AbuseMartina Di Paolo0Antonia Calabrese1Guido Nosari2Valentina Ciappolino3Luisa Cirella4Alice Caldiroli5Enrico Capuzzi6Massimo Clerici7Massimiliano Buoli8Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, ItalyDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyHealthcare Professionals Department, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyPsychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyPsychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyPsychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy<b>Background:</b> The present retrospective observational study aims to identify differences in clinical features and peripheral biomarkers among patients affected by substance-induced psychotic disorder (SIPD) according to the primary substance of abuse. <b>Methods:</b> A sample of 218 patients was divided into three groups according to the type of consumed substance: alcohol, cannabis, and psychostimulants. The three groups were compared using one-way analyses of variance (ANOVAs) for continuous variables and χ<sup>2</sup> tests for qualitative variables. After excluding the alcohol-induced psychotic disorder group, the same analyses were repeated. The statistically significant variables from these subsequent analyses were included in a binary logistic regression model to confirm their reliability as predictors of cannabis- or psychostimulant-induced psychotic disorder. <b>Results:</b> Psychotic cannabis abusers were younger (<i>p</i> < 0.01), with illness onset at an earlier age (<i>p</i> < 0.01). Alcohol consumers presented a longer duration of illness (<i>p</i> < 0.01), more frequent previous hospitalizations (<i>p</i> = 0.04) and medical comorbidities (<i>p</i> < 0.01), and higher mean Modified Sad Persons Scale scores (<i>p</i> < 0.01). Finally, psychostimulant abusers had a higher frequency of lifetime history of poly-substance use disorders (<i>p</i> < 0.01). A binary logistic regression analysis revealed that higher mean Brief Psychiatric Rating Scale scores (<i>p</i> < 0.01) and higher sodium (<i>p</i> = 0.012) and hemoglobin (<i>p</i> = 0.040) plasma levels were predictors of cannabis misuse in SIPD patients. <b>Conclusions:</b> Different clinical factors and biochemical parameters con be associated with SIPD according to the main substance of abuse, thus requiring specific management by clinicians.https://www.mdpi.com/2075-4426/14/3/325alcoholcannabisclinical variablesperipheral biomarkerspsychostimulantssubstance-induced psychotic disorder |
| spellingShingle | Martina Di Paolo Antonia Calabrese Guido Nosari Valentina Ciappolino Luisa Cirella Alice Caldiroli Enrico Capuzzi Massimo Clerici Massimiliano Buoli Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse Journal of Personalized Medicine alcohol cannabis clinical variables peripheral biomarkers psychostimulants substance-induced psychotic disorder |
| title | Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse |
| title_full | Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse |
| title_fullStr | Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse |
| title_full_unstemmed | Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse |
| title_short | Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse |
| title_sort | clinical variables and peripheral biomarkers associated with substance induced psychotic disorder differences related to alcohol cannabis and psychostimulant abuse |
| topic | alcohol cannabis clinical variables peripheral biomarkers psychostimulants substance-induced psychotic disorder |
| url | https://www.mdpi.com/2075-4426/14/3/325 |
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