Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms
Outer membrane vesicles (OMVs) are valued for their unique, convenient, and amendable functions. They are flexible, controllable nanoparticles, which can be modified in different ways, for use in a wide array of applications like adjuvants, vaccines, drug presentation, and fluorescence tracking. Att...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Materials |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmats.2020.00202/full |
| _version_ | 1819194726711033856 |
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| author | Ruizhen Li Qiong Liu Qiong Liu |
| author_facet | Ruizhen Li Qiong Liu Qiong Liu |
| author_sort | Ruizhen Li |
| collection | DOAJ |
| description | Outer membrane vesicles (OMVs) are valued for their unique, convenient, and amendable functions. They are flexible, controllable nanoparticles, which can be modified in different ways, for use in a wide array of applications like adjuvants, vaccines, drug presentation, and fluorescence tracking. Attempts have been made to alter the nanoparticles in liposomes and bacterial ghosts using traditional methods. However, it has not been highly successful owing to certain unavoidable disadvantages. OMVs have unique advantages and are considered novel platforms for heterologous protein presentation. Although previous reviews have described this to some extent, owing to the rapid development in this field, there is a need for the regular update of the reviews. This review focuses on few novel applications of engineered OMVs, and redefines the significance of OMVs as novel multifunctional delivery platforms. Additionally, this review also supplements and provides an update on the OMV transformation methods. |
| first_indexed | 2024-12-23T02:01:27Z |
| format | Article |
| id | doaj.art-df7e159ba3ca4fa4aea1d851ecbaa25b |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-23T02:01:27Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-df7e159ba3ca4fa4aea1d851ecbaa25b2022-12-21T18:03:58ZengFrontiers Media S.A.Frontiers in Materials2296-80162020-07-01710.3389/fmats.2020.00202530186Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery PlatformsRuizhen Li0Qiong Liu1Qiong Liu2Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang, ChinaDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang, ChinaKey Laboratory of Tumor Pathogenesis and Molecular Pathology, School of Medicine, Nanchang University, Nanchang, ChinaOuter membrane vesicles (OMVs) are valued for their unique, convenient, and amendable functions. They are flexible, controllable nanoparticles, which can be modified in different ways, for use in a wide array of applications like adjuvants, vaccines, drug presentation, and fluorescence tracking. Attempts have been made to alter the nanoparticles in liposomes and bacterial ghosts using traditional methods. However, it has not been highly successful owing to certain unavoidable disadvantages. OMVs have unique advantages and are considered novel platforms for heterologous protein presentation. Although previous reviews have described this to some extent, owing to the rapid development in this field, there is a need for the regular update of the reviews. This review focuses on few novel applications of engineered OMVs, and redefines the significance of OMVs as novel multifunctional delivery platforms. Additionally, this review also supplements and provides an update on the OMV transformation methods.https://www.frontiersin.org/article/10.3389/fmats.2020.00202/fullgenetic engineeringmultifunctional delivery platformouter membrane vesicles (OMVs)LPSClyAAT |
| spellingShingle | Ruizhen Li Qiong Liu Qiong Liu Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms Frontiers in Materials genetic engineering multifunctional delivery platform outer membrane vesicles (OMVs) LPS ClyA AT |
| title | Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms |
| title_full | Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms |
| title_fullStr | Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms |
| title_full_unstemmed | Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms |
| title_short | Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms |
| title_sort | engineered bacterial outer membrane vesicles as multifunctional delivery platforms |
| topic | genetic engineering multifunctional delivery platform outer membrane vesicles (OMVs) LPS ClyA AT |
| url | https://www.frontiersin.org/article/10.3389/fmats.2020.00202/full |
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