Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial
Introduction: As no specific pharmacological intervention has been known for COVID-19, medicinal plants may be a suitable candidate for management of this disease. The aim of this study was to investigate the efficacy of a herbal syrup from licorice as an adjuvant treatment in hospitalized patients...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947622001292 |
| _version_ | 1828088724731199488 |
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| author | Saeed Soleiman-Meigooni Nafiseh Hoseini Yekta Hamid Reza Sheikhan Mohammad Aminianfar Ramin Hamidi-Farahani Mousa Ahmadi Ali Asgari Mohammad Hasan Kazemi-Galougahi Roja Rahimi |
| author_facet | Saeed Soleiman-Meigooni Nafiseh Hoseini Yekta Hamid Reza Sheikhan Mohammad Aminianfar Ramin Hamidi-Farahani Mousa Ahmadi Ali Asgari Mohammad Hasan Kazemi-Galougahi Roja Rahimi |
| author_sort | Saeed Soleiman-Meigooni |
| collection | DOAJ |
| description | Introduction: As no specific pharmacological intervention has been known for COVID-19, medicinal plants may be a suitable candidate for management of this disease. The aim of this study was to investigate the efficacy of a herbal syrup from licorice as an adjuvant treatment in hospitalized patients with COVID-19. Materials and methods: 213 hospitalized patients diagnosed with COVID-19 were assigned to receive either standardized licorice syrup as an adjuvant treatment plus standard care [Syrup Group (SYRUP), N = 91], or standard care alone [Standard Group (STANDARD), N = 104], for 7 days. The primary endpoint was duration of hospitalization in survivors. The secondary endpoints included 25% increase in oxygen saturation, C-reactive protein (CRP) difference and lymphocyte difference from baseline, number of death and number of patients transferred to ICU. Results: Mean duration of admission was 5.24 days in SYRUP and 7.14 days in STANDARD (p < 0.001). Oxygen saturation increased in 86 of 91 patients (94.5%) in the licorice group, compared to 83 of 104 patients (79.8%) in the control group (p = 0.002). There was no significant difference between the two groups in the number of patients died during hospitalization (p = 0.837). Five patients in SYRUP and 16 patients in STANDARD were transferred to ICU (p < 0.026). Mean reduction in CRP (p < 0.001) and mean increase in the number of lymphocytes (p = 0.008) in SYRUP were significantly higher than STANDARD. Discussion: Licorice syrup as an adjuvant treatment demonstrated promising results on duration of hospital admission, O2 saturation as well as inflammatory markers in COVID-19 patients; however, further clinical studies with larger sample size are suggested to achieve more conclusive results. |
| first_indexed | 2024-04-11T05:29:49Z |
| format | Article |
| id | doaj.art-df7e7e3d466a4a4f9de73cc0b342f42c |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-04-11T05:29:49Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-df7e7e3d466a4a4f9de73cc0b342f42c2022-12-23T04:37:37ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762022-10-01134100670Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trialSaeed Soleiman-Meigooni0Nafiseh Hoseini Yekta1Hamid Reza Sheikhan2Mohammad Aminianfar3Ramin Hamidi-Farahani4Mousa Ahmadi5Ali Asgari6Mohammad Hasan Kazemi-Galougahi7Roja Rahimi8Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, IranDepartment of Persian Medicine, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranFaculty of Agriculture and Natural Resources, Islamic Azad University, Karaj Branch, Karaj, IranDepartment of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranDepartment of Epidemiology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, IranDepartment of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author.Introduction: As no specific pharmacological intervention has been known for COVID-19, medicinal plants may be a suitable candidate for management of this disease. The aim of this study was to investigate the efficacy of a herbal syrup from licorice as an adjuvant treatment in hospitalized patients with COVID-19. Materials and methods: 213 hospitalized patients diagnosed with COVID-19 were assigned to receive either standardized licorice syrup as an adjuvant treatment plus standard care [Syrup Group (SYRUP), N = 91], or standard care alone [Standard Group (STANDARD), N = 104], for 7 days. The primary endpoint was duration of hospitalization in survivors. The secondary endpoints included 25% increase in oxygen saturation, C-reactive protein (CRP) difference and lymphocyte difference from baseline, number of death and number of patients transferred to ICU. Results: Mean duration of admission was 5.24 days in SYRUP and 7.14 days in STANDARD (p < 0.001). Oxygen saturation increased in 86 of 91 patients (94.5%) in the licorice group, compared to 83 of 104 patients (79.8%) in the control group (p = 0.002). There was no significant difference between the two groups in the number of patients died during hospitalization (p = 0.837). Five patients in SYRUP and 16 patients in STANDARD were transferred to ICU (p < 0.026). Mean reduction in CRP (p < 0.001) and mean increase in the number of lymphocytes (p = 0.008) in SYRUP were significantly higher than STANDARD. Discussion: Licorice syrup as an adjuvant treatment demonstrated promising results on duration of hospital admission, O2 saturation as well as inflammatory markers in COVID-19 patients; however, further clinical studies with larger sample size are suggested to achieve more conclusive results.http://www.sciencedirect.com/science/article/pii/S0975947622001292CoronaSARS-CoV-2Medicinal plantLicoriceInflammationLymphocyte |
| spellingShingle | Saeed Soleiman-Meigooni Nafiseh Hoseini Yekta Hamid Reza Sheikhan Mohammad Aminianfar Ramin Hamidi-Farahani Mousa Ahmadi Ali Asgari Mohammad Hasan Kazemi-Galougahi Roja Rahimi Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial Journal of Ayurveda and Integrative Medicine Corona SARS-CoV-2 Medicinal plant Licorice Inflammation Lymphocyte |
| title | Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial |
| title_full | Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial |
| title_fullStr | Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial |
| title_full_unstemmed | Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial |
| title_short | Efficacy of a standardized herbal formulation from Glycyrrhiza glabra L. as an adjuvant treatment in hospitalized patients with COVID-19: A Randomized Controlled trial |
| title_sort | efficacy of a standardized herbal formulation from glycyrrhiza glabra l as an adjuvant treatment in hospitalized patients with covid 19 a randomized controlled trial |
| topic | Corona SARS-CoV-2 Medicinal plant Licorice Inflammation Lymphocyte |
| url | http://www.sciencedirect.com/science/article/pii/S0975947622001292 |
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