Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study
Jinjuan Duan,* Xia Ju,* Xing Wang, Ning Liu, Siqi Xu, Shengbin Wang Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, Anqing, People’s Republic of China*These authors contributed equally to this workCorrespo...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/effects-of-remimazolam-and-propofol-on-emergence-agitation-in-elderly--peer-reviewed-fulltext-article-DDDT |
| _version_ | 1827825599024988160 |
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| author | Duan J Ju X Wang X Liu N Xu S Wang S |
| author_facet | Duan J Ju X Wang X Liu N Xu S Wang S |
| author_sort | Duan J |
| collection | DOAJ |
| description | Jinjuan Duan,* Xia Ju,* Xing Wang, Ning Liu, Siqi Xu, Shengbin Wang Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, Anqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Siqi Xu; Shengbin Wang, Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, No. 87 Tianzhushan Road, Anqing, 246000, People’s Republic of China, Tel +86-13865192106 ; +86-13955665151, Email errtg555@163.com; shbw1965@126.comPurpose: The aim of this study was to compare the effects of remimazolam and propofol on emergence agitation (EA) in elderly patients undergoing hip replacement.Methods: A total of 60 elderly patients undergoing hip replacement were recruited for this prospective, single-center, clinical, randomized, controlled study from February to April 2023. They were randomly assigned to two groups: the remimazolam group (group R) and the propofol group (group P). In group R, remimazolam was administered intravenously during the induction and maintenance of anesthesia, In group P, propofol was used during the induction and maintenance of anesthesia. The incidence of EA was recorded as the primary indicator. Secondary indicators included heart rate (HR) and mean arterial pressure (MAP) values at the following moments: 5 min prior to anesthetic induction (T0), 1 min following induction (T1), 5 min after the laryngeal mask was inserted (T2), the beginning of surgery (T3), the moment the laryngeal mask was removed (T4), and the overall incidence of postoperative adverse events (bleeding or splitting of the surgical incision, removal of the intravenous infusion needle, falling off the bed, hypoxemia, and hypertension).Results: The incidence of EA was significantly lower in group R than in group P (10% vs 33%, P < 0.05). At T1, T2, and T3, the HR and MAP values of group R were higher than those of group P (P < 0.05). The overall incidence of postoperative adverse events was significantly lower in group R than in group P (P < 0.05).Conclusion: Remimazolam further reduced the incidence of emergence agitation when compared to propofol during geriatric hip replacement. Moreover, it has a minor hemodynamic effect and lower the incidence of postoperative adverse events.Keywords: remimazolam, propofol, emergence agitation, elderly, hip replacement |
| first_indexed | 2024-03-12T02:52:40Z |
| format | Article |
| id | doaj.art-df81322651e745888ffd84b6bfdc012d |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-03-12T02:52:40Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-df81322651e745888ffd84b6bfdc012d2023-09-03T19:02:41ZengDove Medical PressDrug Design, Development and Therapy1177-88812023-09-01Volume 172669267886355Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled StudyDuan JJu XWang XLiu NXu SWang SJinjuan Duan,* Xia Ju,* Xing Wang, Ning Liu, Siqi Xu, Shengbin Wang Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, Anqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Siqi Xu; Shengbin Wang, Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, No. 87 Tianzhushan Road, Anqing, 246000, People’s Republic of China, Tel +86-13865192106 ; +86-13955665151, Email errtg555@163.com; shbw1965@126.comPurpose: The aim of this study was to compare the effects of remimazolam and propofol on emergence agitation (EA) in elderly patients undergoing hip replacement.Methods: A total of 60 elderly patients undergoing hip replacement were recruited for this prospective, single-center, clinical, randomized, controlled study from February to April 2023. They were randomly assigned to two groups: the remimazolam group (group R) and the propofol group (group P). In group R, remimazolam was administered intravenously during the induction and maintenance of anesthesia, In group P, propofol was used during the induction and maintenance of anesthesia. The incidence of EA was recorded as the primary indicator. Secondary indicators included heart rate (HR) and mean arterial pressure (MAP) values at the following moments: 5 min prior to anesthetic induction (T0), 1 min following induction (T1), 5 min after the laryngeal mask was inserted (T2), the beginning of surgery (T3), the moment the laryngeal mask was removed (T4), and the overall incidence of postoperative adverse events (bleeding or splitting of the surgical incision, removal of the intravenous infusion needle, falling off the bed, hypoxemia, and hypertension).Results: The incidence of EA was significantly lower in group R than in group P (10% vs 33%, P < 0.05). At T1, T2, and T3, the HR and MAP values of group R were higher than those of group P (P < 0.05). The overall incidence of postoperative adverse events was significantly lower in group R than in group P (P < 0.05).Conclusion: Remimazolam further reduced the incidence of emergence agitation when compared to propofol during geriatric hip replacement. Moreover, it has a minor hemodynamic effect and lower the incidence of postoperative adverse events.Keywords: remimazolam, propofol, emergence agitation, elderly, hip replacementhttps://www.dovepress.com/effects-of-remimazolam-and-propofol-on-emergence-agitation-in-elderly--peer-reviewed-fulltext-article-DDDTremimazolampropofolemergence agitationelderlyhip replacement |
| spellingShingle | Duan J Ju X Wang X Liu N Xu S Wang S Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study Drug Design, Development and Therapy remimazolam propofol emergence agitation elderly hip replacement |
| title | Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study |
| title_full | Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study |
| title_fullStr | Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study |
| title_full_unstemmed | Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study |
| title_short | Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study |
| title_sort | effects of remimazolam and propofol on emergence agitation in elderly patients undergoing hip replacement a clinical randomized controlled study |
| topic | remimazolam propofol emergence agitation elderly hip replacement |
| url | https://www.dovepress.com/effects-of-remimazolam-and-propofol-on-emergence-agitation-in-elderly--peer-reviewed-fulltext-article-DDDT |
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