NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift assay for nuclear extracts in Bmpr2R899X mouse lung an...

Full description

Bibliographic Details
Main Authors:	Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West
Format:	Article
Language:	English
Published:	MDPI AG 2014-05-01
Series:	Diseases
Subjects:	pulmonary arterial hypertension bone morphogenic protein receptor type 2 NF-κB inflammation
Online Access:	http://www.mdpi.com/2079-9721/2/2/148

Similar Items

NF-κB and Its Regulators During Pregnancy
by: Fernando Gómez-Chávez, et al.
Published: (2021-05-01)

At the crossroads of SUMO and NF-κB
by: Schmidt Christian, et al.
Published: (2003-11-01)

NF-κB in Hematological Malignancies
by: Véronique Imbert, et al.
Published: (2017-05-01)

The Links between ALS and NF-κB
by: Emma Källstig, et al.
Published: (2021-04-01)

The Ubiquitination of NF-κB Subunits in the Control of Transcription
by: Patricia E. Collins, et al.
Published: (2016-05-01)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
by: Carlota Colomer, et al.
Published: (2017-05-01)

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism
by: Liyao Deng, et al.
Published: (2018-08-01)

NF-κB as an Inducible Regulator of Inflammation in the Central Nervous System
by: Sudha Anilkumar, et al.
Published: (2024-03-01)

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases
by: Li Tao, et al.
Published: (2022-07-01)

Targeting the Non-Canonical NF-κB Pathway in Chronic Lymphocytic Leukemia and Multiple Myeloma
by: Thomas A. Burley, et al.
Published: (2022-03-01)

NF-κB: A Druggable Target in Acute Myeloid Leukemia
by: Barbara Di Francesco, et al.
Published: (2022-07-01)

The Regulation of NF-κB Subunits by Phosphorylation
by: Frank Christian, et al.
Published: (2016-03-01)

NFκB signaling in alveolar rhabdomyosarcoma
by: Megan M. Cleary, et al.
Published: (2017-09-01)

Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine
by: Anna L. Aalto, et al.
Published: (2023-09-01)

Evaluation of rs1957106 Polymorphism of NF-κBI in Glioblastoma Multiforme in Isfahan, Iran
by: Yasaman Sadeghi, et al.
Published: (2019-01-01)

Atypical IκB Bcl3 enhances the generation of the NF-κB p52 homodimer
by: Wenfei Pan, et al.
Published: (2022-08-01)

Phthalate exposure aggravates periodontitis by activating NFκB pathway
by: Wei Wu, et al.
Published: (2024-04-01)

BMP pathway regulation of and by macrophages.
by: Megha Talati, et al.
Published: (2014-01-01)

Role of NF-κB in Platelet Function
by: Kevin Kojok, et al.
Published: (2019-08-01)

NF‐κB signaling in inflammation and cancer
by: Tao Zhang, et al.
Published: (2021-12-01)

Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis
by: Xin Li, et al.
Published: (2021-03-01)

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression
by: Polly Downton, et al.
Published: (2023-05-01)

NF-κB sub-pathways and HIV cure: A revisit
by: Lilly M. Wong, et al.
Published: (2021-01-01)

Expression of TLR9 and NF-κB in condyloma acuminatum
by: Guangwen YIN, et al.
Published: (2021-10-01)

Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms
by: Margherita Sisto, et al.
Published: (2020-08-01)

The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
by: J. Charostad, et al.
Published: (2020-10-01)

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
by: Yifan Zhou, et al.
Published: (2020-03-01)

Skin manifestations of inborn errors of NF-κB
by: Yitong Shen, et al.
Published: (2023-01-01)

NF-κB as potential target in the treatment of melanoma
by: Madonna Gabriele, et al.
Published: (2012-03-01)

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
by: Taku Saito, et al.
Published: (2017-05-01)

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein
by: Ziqiao Yuan, et al.
Published: (2020-05-01)

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways
by: Xin Zhi, et al.
Published: (2020-11-01)

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
by: Shi Yi, et al.
Published: (2023-11-01)

Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways
by: Bingyu Shen, et al.
Published: (2023-02-01)

NF-κB, Mesenchymal Differentiation and Glioblastoma
by: Bakhtiar Yamini
Published: (2018-08-01)

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
by: Andrew Paul, et al.
Published: (2018-10-01)

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models
by: Verónica A. García-García, et al.
Published: (2021-07-01)

Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma
by: Po Yee Chung, et al.
Published: (2018-10-01)

The Role of NF-κB Triggered Inflammation in Cerebral Ischemia
by: Teresa Jover-Mengual, et al.
Published: (2021-05-01)

The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target
by: Daniela Verzella, et al.
Published: (2022-09-01)