High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms
The biological variation of cardiac troponins and the existence of a circadian/diurnal rhythm have been poorly evaluated as only the recently developed high-sensitivity assays (hs-cTn) allow the detection of circulating concentrations of both cardiac troponin I (cTnI) and T (cTnT) in reference subje...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-01-01
|
| Series: | Biotechnology & Biotechnological Equipment |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2021.2013135 |
| _version_ | 1818203438904770560 |
|---|---|
| author | Mario Plebani Andrea Padoan Martina Zaninotto |
| author_facet | Mario Plebani Andrea Padoan Martina Zaninotto |
| author_sort | Mario Plebani |
| collection | DOAJ |
| description | The biological variation of cardiac troponins and the existence of a circadian/diurnal rhythm have been poorly evaluated as only the recently developed high-sensitivity assays (hs-cTn) allow the detection of circulating concentrations of both cardiac troponin I (cTnI) and T (cTnT) in reference subjects and under the cut-off values. Available data seem to demonstrate a circadian rhythm for cTnT but not for cTnI but these data need to be confirmed and in particular it should be better clarified if possible variation may affect currently recommended rapid diagnostic algorithms for safe rule-in and rule-out strategies. Here we report the results obtained using a hs-cTnI assay in 35 subjects who underwent serial samples collection over time. |
| first_indexed | 2024-12-12T03:25:21Z |
| format | Article |
| id | doaj.art-df8240b644ad4648902e8f46bc9daab2 |
| institution | Directory Open Access Journal |
| issn | 1310-2818 1314-3530 |
| language | English |
| last_indexed | 2024-12-12T03:25:21Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj.art-df8240b644ad4648902e8f46bc9daab22022-12-22T00:40:04ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302022-01-0136sup1S5S810.1080/13102818.2021.2013135High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithmsMario Plebani0Andrea Padoan1Martina Zaninotto2Department of Laboratory Medicine, University-Hospital of Padova, Padova, ItalyDepartment of Laboratory Medicine, University-Hospital of Padova, Padova, ItalyDepartment of Laboratory Medicine, University-Hospital of Padova, Padova, ItalyThe biological variation of cardiac troponins and the existence of a circadian/diurnal rhythm have been poorly evaluated as only the recently developed high-sensitivity assays (hs-cTn) allow the detection of circulating concentrations of both cardiac troponin I (cTnI) and T (cTnT) in reference subjects and under the cut-off values. Available data seem to demonstrate a circadian rhythm for cTnT but not for cTnI but these data need to be confirmed and in particular it should be better clarified if possible variation may affect currently recommended rapid diagnostic algorithms for safe rule-in and rule-out strategies. Here we report the results obtained using a hs-cTnI assay in 35 subjects who underwent serial samples collection over time.https://www.tandfonline.com/doi/10.1080/13102818.2021.2013135Cardiac troponinsbiological variationdiurnal rhythmrapid diagnostic algorithmreference change valueindex of individuality |
| spellingShingle | Mario Plebani Andrea Padoan Martina Zaninotto High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms Biotechnology & Biotechnological Equipment Cardiac troponins biological variation diurnal rhythm rapid diagnostic algorithm reference change value index of individuality |
| title | High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms |
| title_full | High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms |
| title_fullStr | High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms |
| title_full_unstemmed | High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms |
| title_short | High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms |
| title_sort | high sensitive cardiac troponin biological variation circadian rhythm and diagnostic algorithms |
| topic | Cardiac troponins biological variation diurnal rhythm rapid diagnostic algorithm reference change value index of individuality |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2021.2013135 |
| work_keys_str_mv | AT marioplebani highsensitivecardiactroponinbiologicalvariationcircadianrhythmanddiagnosticalgorithms AT andreapadoan highsensitivecardiactroponinbiologicalvariationcircadianrhythmanddiagnosticalgorithms AT martinazaninotto highsensitivecardiactroponinbiologicalvariationcircadianrhythmanddiagnosticalgorithms |