Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases
We present five cases in whom two rare entities were simultaneously found within the liver, i.e. hepatocellular adenomas (HCAs) and granulomas. Coexistence of both entities confuses diagnosis. Our aim is to disclose the association between HCA and hepatic granulomas. Five patients presented with HCA...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2012-10-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/343434 |
| _version_ | 1811239922081726464 |
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| author | Matthanja Bieze Paulette Bioulac-Sage Joanne Verheij Charles Balabaud Christophe Laurent Thomas M. van Gulik |
| author_facet | Matthanja Bieze Paulette Bioulac-Sage Joanne Verheij Charles Balabaud Christophe Laurent Thomas M. van Gulik |
| author_sort | Matthanja Bieze |
| collection | DOAJ |
| description | We present five cases in whom two rare entities were simultaneously found within the liver, i.e. hepatocellular adenomas (HCAs) and granulomas. Coexistence of both entities confuses diagnosis. Our aim is to disclose the association between HCA and hepatic granulomas. Five patients presented with HCA for which they underwent resection. During laparotomy or at pathological examination, granulomas were found in tumorous and non-tumorous tissue. No specific cause for the granulomas was found. Immunohistochemistry showed overexpression of C-reactive protein and serum amyloid A in 4/5 patients, classifying these lesions as inflammatory HCA. HCA and especially the inflammatory subtype may cause formation of granulomas in (peri-)tumorous tissue as a local response to persistent inflammation and/or the presence of a tumor. Both HCA and hepatic granulomas have also been associated with oral contraceptive use. In conclusion, HCAs associated with hepatic granulomas derive from a local response to (inflammatory) HCA or neoplasm, chronic use of oral contraceptives, or a combination of these factors. |
| first_indexed | 2024-04-12T13:09:42Z |
| format | Article |
| id | doaj.art-df8508d6b9ae4ca9a32f4ae319cf13c6 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-12T13:09:42Z |
| publishDate | 2012-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-df8508d6b9ae4ca9a32f4ae319cf13c62022-12-22T03:31:55ZengKarger PublishersCase Reports in Gastroenterology1662-06312012-10-016367768310.1159/000343434343434Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five CasesMatthanja BiezePaulette Bioulac-SageJoanne VerheijCharles BalabaudChristophe LaurentThomas M. van GulikWe present five cases in whom two rare entities were simultaneously found within the liver, i.e. hepatocellular adenomas (HCAs) and granulomas. Coexistence of both entities confuses diagnosis. Our aim is to disclose the association between HCA and hepatic granulomas. Five patients presented with HCA for which they underwent resection. During laparotomy or at pathological examination, granulomas were found in tumorous and non-tumorous tissue. No specific cause for the granulomas was found. Immunohistochemistry showed overexpression of C-reactive protein and serum amyloid A in 4/5 patients, classifying these lesions as inflammatory HCA. HCA and especially the inflammatory subtype may cause formation of granulomas in (peri-)tumorous tissue as a local response to persistent inflammation and/or the presence of a tumor. Both HCA and hepatic granulomas have also been associated with oral contraceptive use. In conclusion, HCAs associated with hepatic granulomas derive from a local response to (inflammatory) HCA or neoplasm, chronic use of oral contraceptives, or a combination of these factors.http://www.karger.com/Article/FullText/343434LiverHepatocellular adenomaHepatic granulomaBenignOral contraceptivesInflammation |
| spellingShingle | Matthanja Bieze Paulette Bioulac-Sage Joanne Verheij Charles Balabaud Christophe Laurent Thomas M. van Gulik Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases Case Reports in Gastroenterology Liver Hepatocellular adenoma Hepatic granuloma Benign Oral contraceptives Inflammation |
| title | Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases |
| title_full | Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases |
| title_fullStr | Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases |
| title_full_unstemmed | Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases |
| title_short | Hepatocellular Adenomas Associated with Hepatic Granulomas: Experience in Five Cases |
| title_sort | hepatocellular adenomas associated with hepatic granulomas experience in five cases |
| topic | Liver Hepatocellular adenoma Hepatic granuloma Benign Oral contraceptives Inflammation |
| url | http://www.karger.com/Article/FullText/343434 |
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