Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients

Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients

<p>Abstract</p> <p>Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in various tumor entities. It is unclear yet whether a TCR r...

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Bibliographic Details
Main Authors: Thiel Eckhard, Nüssler Natascha C, Busse Antonia, Wojtke Susanne, Fusi Alberto, Ochsenreither Sebastian, Keilholz Ulrich, Nagorsen Dirk
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/35

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