A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity

A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity

Mammalian INDY (mINDY, NaCT, gene symbol <i>SLC13A5</i>) is a potential target for the treatment of metabolically associated fatty liver disease (MAFLD). This study evaluated the effects of a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT. First, t...

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Bibliographic Details
Main Authors: Grit Zahn, Diana M. Willmes, Nermeen N. El-Agroudy, Christopher Yarnold, Richard Jarjes-Pike, Sabine Schaertl, Kay Schreiter, Wiebke Gehrmann, Andrea Kuan Cie Wong, Tommaso Zordan, Jörg König, Jens Jordan, Andreas L. Birkenfeld
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Metabolites
Subjects:
MAFLD
NASH
NAFLD
mINDY
SLC13A5
citrate transporter
Online Access:https://www.mdpi.com/2218-1989/12/8/732

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