Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders
Calcium (Ca2+) comprises a critical ionic second messenger in the central nervous system that is under the control of a wide array of regulatory mechanisms, including organellar Ca2+ stores, membrane channels and pumps, and intracellular Ca2+-binding proteins. Not surprisingly, disturbances in Ca2+...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1093099/full |
| _version_ | 1797924606514823168 |
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| author | Benjamin Klocke Kylie Krone Jason Tornes Carter Moore Hayden Ott Pothitos M. Pitychoutis |
| author_facet | Benjamin Klocke Kylie Krone Jason Tornes Carter Moore Hayden Ott Pothitos M. Pitychoutis |
| author_sort | Benjamin Klocke |
| collection | DOAJ |
| description | Calcium (Ca2+) comprises a critical ionic second messenger in the central nervous system that is under the control of a wide array of regulatory mechanisms, including organellar Ca2+ stores, membrane channels and pumps, and intracellular Ca2+-binding proteins. Not surprisingly, disturbances in Ca2+ homeostasis have been linked to neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, aberrations in Ca2+ homeostasis have also been implicated in neuropsychiatric disorders with a strong neurodevelopmental component including autism spectrum disorder (ASD) attention-deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ). While plasma membrane Ca2+ channels and synaptic Ca2+-binding proteins have been extensively studied, increasing evidence suggests a prominent role for intracellular Ca2+ stores, such as the endoplasmic reticulum (ER), in aberrant neurodevelopment. In the context of the current mini-review, we discuss recent findings implicating critical intracellular Ca2+-handling regulators such as the sarco-ER Ca2+ ATPase 2 (SERCA2), ryanodine receptors (RyRs), inositol triphosphate receptors (IP3Rs), and parvalbumin (PVALB), in the emergence of ASD, SCZ, and ADHD. |
| first_indexed | 2024-04-10T15:04:42Z |
| format | Article |
| id | doaj.art-df885efff4fd476c81c5043fd1ff14f0 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T15:04:42Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-df885efff4fd476c81c5043fd1ff14f02023-02-15T08:38:43ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.10930991093099Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disordersBenjamin KlockeKylie KroneJason TornesCarter MooreHayden OttPothitos M. PitychoutisCalcium (Ca2+) comprises a critical ionic second messenger in the central nervous system that is under the control of a wide array of regulatory mechanisms, including organellar Ca2+ stores, membrane channels and pumps, and intracellular Ca2+-binding proteins. Not surprisingly, disturbances in Ca2+ homeostasis have been linked to neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, aberrations in Ca2+ homeostasis have also been implicated in neuropsychiatric disorders with a strong neurodevelopmental component including autism spectrum disorder (ASD) attention-deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ). While plasma membrane Ca2+ channels and synaptic Ca2+-binding proteins have been extensively studied, increasing evidence suggests a prominent role for intracellular Ca2+ stores, such as the endoplasmic reticulum (ER), in aberrant neurodevelopment. In the context of the current mini-review, we discuss recent findings implicating critical intracellular Ca2+-handling regulators such as the sarco-ER Ca2+ ATPase 2 (SERCA2), ryanodine receptors (RyRs), inositol triphosphate receptors (IP3Rs), and parvalbumin (PVALB), in the emergence of ASD, SCZ, and ADHD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1093099/fullautismSERCA2ryanodine receptorscalciumschizophreniaattention-deficit hyperactivity disorder (ADHD) |
| spellingShingle | Benjamin Klocke Kylie Krone Jason Tornes Carter Moore Hayden Ott Pothitos M. Pitychoutis Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders Frontiers in Neuroscience autism SERCA2 ryanodine receptors calcium schizophrenia attention-deficit hyperactivity disorder (ADHD) |
| title | Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| title_full | Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| title_fullStr | Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| title_full_unstemmed | Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| title_short | Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| title_sort | insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders |
| topic | autism SERCA2 ryanodine receptors calcium schizophrenia attention-deficit hyperactivity disorder (ADHD) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1093099/full |
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